Publication Date:
2010-07-31
Description:
The planar cell polarity (PCP) signaling pathway governs collective cell movements during vertebrate embryogenesis, and certain PCP proteins are also implicated in the assembly of cilia. The septins are cytoskeletal proteins controlling behaviors such as cell division and migration. Here, we identified control of septin localization by the PCP protein Fritz as a crucial control point for both collective cell movement and ciliogenesis in Xenopus embryos. We also linked mutations in human Fritz to Bardet-Biedl and Meckel-Gruber syndromes, a notable link given that other genes mutated in these syndromes also influence collective cell movement and ciliogenesis. These findings shed light on the mechanisms by which fundamental cellular machinery, such as the cytoskeleton, is regulated during embryonic development and human disease.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3509789/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3509789/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kim, Su Kyoung -- Shindo, Asako -- Park, Tae Joo -- Oh, Edwin C -- Ghosh, Srimoyee -- Gray, Ryan S -- Lewis, Richard A -- Johnson, Colin A -- Attie-Bittach, Tania -- Katsanis, Nicholas -- Wallingford, John B -- G0700073/Medical Research Council/United Kingdom -- P50 MH094268/MH/NIMH NIH HHS/ -- R01 DK072301/DK/NIDDK NIH HHS/ -- R01 DK075972/DK/NIDDK NIH HHS/ -- R01 GM074104/GM/NIGMS NIH HHS/ -- R01 HD042601/HD/NICHD NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2010 Sep 10;329(5997):1337-40. doi: 10.1126/science.1191184. Epub 2010 Jul 29.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Section of Molecular Cell and Developmental Biology and Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, TX 78712, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20671153" target="_blank"〉PubMed〈/a〉
Keywords:
Abnormalities, Multiple/genetics
;
Animals
;
Bardet-Biedl Syndrome/*genetics
;
Cell Membrane/metabolism/ultrastructure
;
*Cell Movement
;
*Cell Polarity
;
Cell Shape
;
Cilia/*metabolism/ultrastructure
;
Cytoskeletal Proteins/genetics/*metabolism
;
Cytoskeleton/*metabolism/ultrastructure
;
Embryo, Nonmammalian/cytology/physiology
;
Embryonic Development
;
Female
;
GTP-Binding Proteins/genetics/*metabolism
;
Gastrula/cytology
;
Genetic Association Studies
;
Glycoproteins/genetics/*metabolism
;
Hedgehog Proteins/metabolism
;
Humans
;
Morphogenesis
;
Mutant Proteins/metabolism
;
Mutation
;
Septins
;
Syndrome
;
Xenopus Proteins/genetics/*metabolism
;
Xenopus laevis
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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