Publication Date:
1985-05-03
Description:
In studying the origins of life, it is important to examine reactions of substrate mixtures that could plausibly have accumulated on the primitive earth. Nucleoside diphosphates would probably have been synthesized along with the standard nucleotides under prebiotic conditions. For these reasons, the template-directed reactions of activated derivatives of these diphosphates, alone or mixed with activated nucleotides, were investigated. An activated derivative of deoxyguanosine 3',5'-diphosphate condensed efficiently on a polycytidylate template to give oligonucleotide analogues in which each 3',5'-phosphodiester bond was replaced by a pyrophosphate linkage. Oligomers were formed even in the absence of a template, but much more slowly. Template-directed condensation occurred also with an analogous deoxyadenosine derivative on polyuridylic acid and with an analogous acycloguanosine derivative on polycytidylic acid.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schwartz, A W -- Orgel, L E -- New York, N.Y. -- Science. 1985 May 3;228:585-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Salk Insitute for Biological Sciences, San Diego, California 92138, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11541994" target="_blank"〉PubMed〈/a〉
Keywords:
Cytosine/chemistry
;
Deoxyguanine Nucleotides/chemistry
;
Evolution, Molecular
;
Guanine/chemistry
;
Nucleic Acids/*chemical synthesis
;
Oligonucleotides/*chemical synthesis
;
*Origin of Life
;
Poly C/chemistry
;
Poly U/chemistry
;
Templates, Genetic
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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