Publication Date:
1987-01-09
Description:
The HER-2/neu oncogene is a member of the erbB-like oncogene family, and is related to, but distinct from, the epidermal growth factor receptor. This gene has been shown to be amplified in human breast cancer cell lines. In the current study, alterations of the gene in 189 primary human breast cancers were investigated. HER-2/neu was found to be amplified from 2- to greater than 20-fold in 30% of the tumors. Correlation of gene amplification with several disease parameters was evaluated. Amplification of the HER-2/neu gene was a significant predictor of both overall survival and time to relapse in patients with breast cancer. It retained its significance even when adjustments were made for other known prognostic factors. Moreover, HER-2/neu amplification had greater prognostic value than most currently used prognostic factors, including hormonal-receptor status, in lymph node-positive disease. These data indicate that this gene may play a role in the biologic behavior and/or pathogenesis of human breast cancer.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Slamon, D J -- Clark, G M -- Wong, S G -- Levin, W J -- Ullrich, A -- McGuire, W L -- CA 30195/CA/NCI NIH HHS/ -- CA 36827/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1987 Jan 9;235(4785):177-82.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3798106" target="_blank"〉PubMed〈/a〉
Keywords:
Axilla
;
Breast Neoplasms/*genetics/mortality/pathology
;
DNA/genetics
;
Female
;
*Gene Amplification
;
Humans
;
Lymph Nodes/pathology
;
Neoplasm Recurrence, Local/*genetics
;
Nucleic Acid Hybridization
;
*Oncogenes
;
Prognosis
;
Receptor, Epidermal Growth Factor/genetics
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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