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  • Atherosclerosis  (1)
  • Breast tumours  (1)
  • COMPOSITE MATERIALS  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Medical & biological engineering & computing 17 (1979), S. 45-60 
    ISSN: 1741-0444
    Keywords: Biomedical dielectrics ; Breast tumours ; Fourier transforms ; In vivo measurements
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract An instrument is described for measuring the relative permittivity and dielectric loss of body tissues and organsin vivo, over the frequency range 0·1 Hz to about 100 kHz. A voltage transient is applied by means of suitable electrodes and the resulting waveform is sampled, digitised and Fourier transformed using a microprocessor to give a spectrum in the frequency domain. The results show differences in relative permittivity and dielectric loss between different types of tissue. Much of the preliminary clinical work with this apparatus has been done using measurements on breast tumours.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1573-9686
    Keywords: ICAM-1 ; VCAM-1 ; Selectins ; Flow ; Atherosclerosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Technology
    Notes: Abstract Extensive monocyte recruitment is an early phenomenon associated with the development of atherosclerotic lesions, suggesting an active role for the involvement of adhesion receptors expressed by endothelial cells. In this study we describe the contribution of hemodynamic shear forces in regulating the expression of a few of the monocyte adhesion receptors, including intercellular adhesion molecule (ICAM-1), vascular cell adhesion molecule (VCAM-1), and E-selectin on endothelial cells. A parallel plate flow chamber and recirculating flow loop device was used to expose human umbilical vein endothelial cells (HUVECs) to different levels of shear (2–25 dyn/cm2). Subsequently the cells were analyzed either for shear induced changes in the mRNA levels of adhesion receptors by Northern blot analyses or for changes in the surface expression of ICAM-1 using flow cytometry. Results from the fluorescence analysis showed a transient increase in the surface expression of ICAM-1, 12 hr after exposure to 25 dyn/cm2 shear, returning to basal levels within 24 hr. This was quite different from the time dependent response of ICAM-1 to lipopolysaccharide (LPS), where ICAM-1 expression was maximally induced 18–24 hr poststimulus. ICAM-1 mRNA level appeared slightly elevated after exposure to shear for 1 hr, compared to basal values, but dropped below basal levels within 6 hr. This biphasic response was seen irrespective of the magnitude of applied shear stress. VCAM-1 mRNA expression, in contrast, decreased below the baseline expression within an hour after onset of flow, and appeared to be considerably down-regulated within 6 hr. After exposure to shear for 24 hr no increase in mRNA levels could be detected for either molecule, at any shear magnitude. E-selectin mRNA was less responsive to shear stress, especially at the lower magnitudes of shear. After an hour of exposure to flow E-selectin mRNA level appeared slightly reduced compared with control levels, but it remained at this level even after 6 hr of flow. These results indicate that the expression of adhesion receptors is sensitive to local shear stresses in a manner that is molecule specific in the short term even though prolonged exposure to flow results in similar down-regulation for both ICAM-1 and VCAM-1.
    Type of Medium: Electronic Resource
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  • 3
    Publication Date: 2019-06-27
    Description: Fabrication techniques for NR-150B2-S5X graphite/polyimide composites are described. The development of fabrication, tooling, and quality assurance techniques used for the composites is discussed. Processing information and preliminary mechanical property data are presented along with long term aging data.
    Keywords: COMPOSITE MATERIALS
    Type: NASA. Langley Res. Center Graphite(Polyimide Composites; p 39-60
    Format: text
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