ISSN:
1612-1112
Keywords:
Gas chromatography (HRGC)
;
Enantiomer separation
;
Enantiomeric excess
;
Hydrogenation reaction of α-ketoesters
;
Asymmetric heterogeneous catalysts
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Summary In this paper, the recently reported chiral stationary phase [1,2] was applied to the chiral resolution of alkyl lactates in the investigation of the effect of a new asymmetric heterogeneous catalyst system (cinchonidine-modified finely dispersed polyvinylpyrrolidone-stabilized platinum clusters) in the enantioselective hydrogenation of α-ketoesters. The enantiomers of methyl, ethyl, isopropyl, n-propyl and n-butyl lactates were successfully resolved while the enantiomers of isobutyl lactate could not be resolved, at all. The separation of the enantiomers of isopropyl, n-propyl and n-butyl lactates are reported for the first time. The results show that the new asymmetric heterogeneous catalyst system is effective in the enantioselective hydrogenation of α-ketoesters.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02467687
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