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  • Astrophysics; Lunar and Planetary Science and Exploration  (1)
  • Key words: Human parathyroid hormone — Trabecular connectivity — Streptozotocin-induced diabetes mellitus — Bone histomorphometry — Node-strut analysis.  (1)
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  • 1
    Electronic Resource
    Electronic Resource
    Histomorphometric Evaluation of the Recovering Effect of Human Parathyroid Hormone (1–34) on Bone Structure and Turnover in Streptozotocin-Induced Diabetic Rats (2000)
    Springer
    Calcified tissue international 66 (2000), S. 229-233 
    Details
    ISSN: 1432-0827
    Keywords: Key words: Human parathyroid hormone — Trabecular connectivity — Streptozotocin-induced diabetes mellitus — Bone histomorphometry — Node-strut analysis.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Abstract. The purpose of this study was to determine whether human parathyroid hormone (h-PTH) enhances trabecular bone mass and connectivities that were reduced by streptozotocin (STZ)-induced diabetes in rats. Seven-month-old female Wistar rats were injected with STZ or its vehicle intraperitoneally. All vehicle-injected normal controls were sacrificed 0, 4, 6, 8, 12, 14, and 16 weeks after injection, and one-third of the STZ-injected rats were sacrificed as the baseline controls 4, 6, and 8 weeks after the injection. Eight-week h-PTH (6.0 μg/kg, 6 times a week) or its vehicle treatment by subcutaneous injection for residual diabetic rats was started 4, 6, or 8 weeks after the STZ injection. The rats' proximal right tibiae were processed for undecalcified Villanueva bone staining sections for bone histomorphometry. Furthermore, changes in trabecular connectivities were determined by node-strut analysis. The decreased cancellous bone volume (BV/TV) and turnover in diabetic rats were recovered in all PTH-treated groups. In node-strut analysis, the node-related parameters (N.Nd/TV, NdNd/TV) were significantly increased by PTH when it was administered 4 weeks after STZ injection but were not increased when administration was started after 6 weeks. The results indicated that PTH enhanced bone turnover and bone mass but not trabecular connectivity in the late stage of diabetes in rats. Early treatment of osteoporosis is important in preventing fractures caused by decreased bone strength resulting from decreased trabecular connectivity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00005838
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    Paper (German National Licenses)
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    High-Contrast Imaging of Epsilon Eridani with Ground-Based Instruments (2016)
    In:  Other Sources
    Details
    Publication Date: 2019-07-13
    Description: Epsilon Eridani is one of the nearest solar-type stars. Its proximity and relatively young age allow high-contrast imaging observations to achieve sensitivities to planets at narrow separations down to an inner radius of approximately 5 AU. Previous observational studies of the system report a dust disk with asymmetric morphology as well as a giant planet with large orbital eccentricity, which may require another massive companion to induce the peculiar morphology and to enhance the large orbital eccentricity. In this paper, we report results from deep high-contrast imaging observations to detect the previously reported planet and search for other unseen less massive companions with Subaru/HiCIAO, Gemini-South/NICI, and VLT/NACO. No positive detection was made, but high-contrast measurements with the CH4S narrow-band filter of HiCIAO achieved sensitivities at 14.7 mag differential magnitude level, at an angular separation of 1.0''. In terms of planetary mass, as determined by cooling evolutionary models, the highest sensitivities were achieved by the Lp broad-band filter of NACO, resulting in sensitivities corresponding to 1.8, 2.8, and 4.5 M(sub jup) at the projected separation of 3 AU, if 200, 400, and 800 Myr is assumed for the age of the system, respectively. We also discuss origins of the dust disk from the detection sensitivity in the planetary mass and find that a less massive eccentric planet is preferred for disk stirring, which is consistent with the orbital parameters of epsilon Eri b claimed from the previous long-term radial velocity monitoring.
    Keywords: Astrophysics; Lunar and Planetary Science and Exploration
    Type: GSFC-E-DAA-TN41499 , Astsronomy & Astrophysics (ISSN 0004-6361) (e-ISSN 1432-0746); 595; A79
    Format: text
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