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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Theoretical and applied genetics 67 (1984), S. 113-122 
    ISSN: 1432-2242
    Keywords: Mice ; Selection ; Growth ; Genetic correlation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Four lines of mice were formed from a common base population and selected for 37 generations for either increased 3-week weight (weaning weight), 6-week weight, 3–6 week gain, or maintained as a randomly bred control line. Realised heritability estimates for short-term (long-term) responses were 0.33±0.20 (0.07±0.10), 0.46±0.14 (0.26±0.09), 0.36±0.14 (0.24±0.11) for 3-week weight, 6-week weight and 3–6 week gain, respectively. Realised genetic correlations estimated from short-term (long-term) responses were 0.23±0.08 (0.35±0.10) between 3-week weight and 3–6 week gain; 0.82±0.04 (0.58±0.08) between 3-week weight and 6-week weight; and 0.81±0.04 (0.97±0.04) between 3–6 week gain and 6-week weight. The genetic correlation between 3-week weight and 6-week weight was asymmetric with a greater correlated response for 3-week weight when selecting for 6-week weight (1.06) than vice versa (0.63).
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Theoretical and applied genetics 81 (1991), S. 685-692 
    ISSN: 1432-2242
    Keywords: IGF-1 ; Body weight ; Realized heritability ; Genetic correlation ; Mice
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Five generations of divergent selection for plasma concentration of insulin-like growth factor-1 (IGF-1) and for 12-week body weight were carried out in mice, including randomly selected control lines for each trait. All lines were replicated once (12 lines in total). Each replicate line consisted of eight male and eight female parents per generation. Litter size was standardized to eight pups at birth. Mass selection was applied in the selected lines and within-family random selection in the control lines. Blood was taken from the orbital sinus of individual mice at 12 weeks of age for IGF-1 assay. Realized heritabilities were 0.10±0.01 for IGF-1 and 0.41 ± 0.02 for 12-week weight. The realized genetic correlation between IGF-1 and 12-week weight was 0.58 ± 0.01, with a phenotypic correlation of 0.38. Although the genetic correlation between IGF-1 and body weight in mice is moderately positive, 12-week weight responded 3.5 times as fast to weight selection as to selection for IGF-1.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Theoretical and applied genetics 76 (1988), S. 148-156 
    ISSN: 1432-2242
    Keywords: Growth curve ; Genetic parameters ; Heritability ; Mice
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Data from 1,919 outbred ICR mice were used to examine the potential usefulness of growth curve parameters as selection criteria for altering the relationship between body weight and age. A logistic growth function was used to model growth through 12 weeks of age. Estimates of asymptotic weight (A), maximum growth rate (r) and age at point of inflection (t*) were obtained by nonlinear least-squares. A log transformation was also used to stabilize residual variance. Phenotypic and genetic parameters were estimated for the estimated growth curve parameters and for body weights at 2, 3, 4.5, 6, 8 and 12 weeks of age. Heritabilities of estimated growth curve parameters (obtained with and without a log transformation, respectively) were: A (0.28±0.07, 0.28±0.07), r (0.35±0.07, 0.53±0.09) and t* (0.41±0.08, 0.44±0.08). Estimated genetic correlations suggest that t* may be useful in selecting for rapid early growth without increasing mature weight.
    Type of Medium: Electronic Resource
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  • 4
    Publication Date: 2018-08-10
    Description: The IMPACT investigation for the STEREO Mission includes a complement of Solar Energetic Particle instruments on each of the two STEREO spacecraft. Of these instruments, the High Energy Telescopes (HETs) provide the highest energy measurements. This paper describes the HETs in detail, including the scientific objectives, the sensors, the overall mechanical and electrical design, and the on-board software. The HETs are designed to measure the abundances and energy spectra of electrons, protons, He, and heavier nuclei up to Fe in interplanetary space. For protons and He that stop in the HET, the kinetic energy range corresponds to approx. 13 to 40 MeV/n. Protons that do not stop in the telescope (referred to as penetrating protons) are measured up to approx. 100 MeV/n, as are penetrating He. For stopping He, the individual isotopes He-3 and He-4 can be distinguished. Stopping electrons are measured in the energy range approx. 0.7 - 6 MeV.
    Keywords: Astronomy
    Type: To appear in Space Science Reviews
    Format: application/pdf
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  • 5
    Publication Date: 2019-07-12
    Description: Motivated by the proposed EXIST mission, a "medium-class" space observatory to survey black holes and the Early Universe proposed to the 2010 NAS/NRC Astronomy and Astrophysics Decadal Survey, we have developed the first "large" area 256 sq cm close-tiled (0.6 mm gaps) hard X-ray (20-600 keV) imaging detector employing pixelated (2.5 mm) CdZnTe (CZT) detectors, each 2 x 2 x 0.5 cubic cm. We summarize the design, development and operation of this detector array (8 x 8 CZTs) and its performance as the imager for a coded aperture telescope on a high altitude (40 km) balloon flight in October. 2009, as the ProtoEX1STl payload. We then outline our current development of a second-generation imager, ProtcEXIST2. with 0.6 mm pixels on a 32 x 32 array on each CZT, and how it will lead to the ultimate imaging system needed for EXIST. Other applications of this technology will also be mentioned.
    Keywords: Astronomy
    Type: GSFC.JA.6610.2012
    Format: text
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  • 6
    Publication Date: 2019-07-17
    Description: We describe the signal processing system of the Astro-E XRS instrument. The Calorimeter Analog Processor (CAP) provides bias and power for the detectors and amplifies the detector signals by a factor of 20,000. The Calorimeter Digital Processor (CDP) performs the digital processing of the calorimeter signals, detecting X-ray pulses and analyzing them by optimal filtering. We describe the operation of pulse detection, pulse height analysis, and risetime determination. We also discuss performance, including the three event grades (hi-res, mid-res, and low-res), anticoincidence detection, counting rate dependence, and noise rejection.
    Keywords: Astronomy
    Type: Jul 18, 1999 - Jul 23, 1999; Denver, CO; United States
    Format: text
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  • 7
    Publication Date: 2019-07-13
    Description: We describe the signal processing system of the Astro-E XRS instrument. The Calorimeter Analog Processor (CAP) provides bias and power for the detectors and amplifies the detector signals by a factor of 20,000. The Calorimeter Digital Processor (CDP) performs the digital processing of the calorimeter signals, detecting X-ray pulses and analyzing them by optimal filtering. We describe the operation of pulse detection, Pulse height analysis. and risetime determination. We also discuss performance, including the three event grades (hi-res mid-res, and low-res). anticoincidence detection, counting rate dependence, and noise rejection.
    Keywords: Astronomy
    Type: Jul 18, 1999 - Jul 23, 1999; Denver, CO; United States
    Format: application/pdf
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  • 8
    Publication Date: 2019-07-13
    Description: Micro-X is a sounding rocket borne X-ray telescope that utilizes transition edge sensors to perform imaging spectroscopy with a high level of energy resolution. Its 2.1m focal length X-ray optic has an effective area of 300 sq cm, a field of view of 11.8 arcmin, and a bandpass of 0.12.5 keV. The detector array has 128 pixels and an intrinsic energy resolution of 4.5 eV FWHM. The integration of the system has progressed with functional tests of the detectors and electronics complete, and performance characterization of the detectors is underway. We present an update of ongoing progress in preparation for the upcoming launch of the instrument.
    Keywords: Astronomy
    Type: GSFC-E-DAA-TN43475 , SPIE Proceedings; 9905; 24|Space Telescopes and Instrumentation 2016; Jun 26, 2016; Edinburgh; United Kingdom
    Format: text
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