ISSN:
1615-6102
Keywords:
Ascorbate stabilization
;
Ascorbate free radical
;
Plasma membrane redox system
;
HL-60 cells
;
Cyclic AMP
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
Notes:
Summary Ascorbate is stabilized in the presence of HL-60 cells. Our results showed that cAMP derivatives and agents that increase cAMP stimulate the ability of HL-60 cells to stabilize ascorbate. On the other hand, tunicamycin, a glycosilation-interfering agent, inhibited this ability. The ascorbate stabilization in the presence of HL-60 cells has been questioned as a simple chemical effect. Further properties and controls about the enzymatic nature of this stabilization are described and discussed. This data, together with hormonal regulation, support the hypothesis that an enzymatic redox system located at the plasma membrane is responsible of the extracellular ascorbate stabilization by HL-60 cells.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01276925
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