Publication Date:
1995-11-24
Description:
An argument is proposed to explain the origin of large metazoans, based on the regulatory processes that underlie the morphogenetic organization of pattern in modern animals. Genetic regulatory systems similar to those used in modern, indirectly developing marine invertebrates are considered to indicate the Precambrian regulatory platform on which were erected innovations that underlie the development of macroscopic body plans. Those systems are genetic regulatory programs that produce groups of unspecified "set-aside cells" and hierarchical regulatory programs that initially define regions of morphogenetic space in terms of domains of transcription factor expression. These ideas affect interpretation of the development of arthropods and chordates as well as interpretation of the role of the genes of the homeotic complex in embryogenesis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Davidson, E H -- Peterson, K J -- Cameron, R A -- HD-05753/HD/NICHD NIH HHS/ -- RR-06591/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 1995 Nov 24;270(5240):1319-25.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Biology, California Institute of Technology, Pasadena 91125, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7481819" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Arthropods/embryology/genetics/growth & development
;
*Biological Evolution
;
Cell Differentiation/genetics
;
Chordata, Nonvertebrate/embryology/genetics/*growth & development
;
*Embryonic Development
;
Fossils
;
*Gene Expression Regulation, Developmental
;
Genes, Homeobox
;
Invertebrates/embryology/genetics/*growth & development
;
Morphogenesis
;
Multigene Family
;
Vertebrates/embryology/genetics/*growth & development
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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