Publication Date:
2003-03-01
Description:
Ecdysone, the major steroid hormone of Drosophila melanogaster, is known for its role in development and reproduction. Flies that are heterozygous for mutations of the ecdysone receptor exhibit increases in life-span and resistance to various stresses, with no apparent deficit in fertility or activity. A mutant involved in the biosynthesis of ecdysone displays similar effects, which are suppressed by feeding ecdysone to the flies. These observations demonstrate the importance of the ecdysone hormonal pathway, a new player in regulating longevity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Simon, Anne F -- Shih, Cindy -- Mack, Antha -- Benzer, Seymour -- AG16630/AG/NIA NIH HHS/ -- New York, N.Y. -- Science. 2003 Feb 28;299(5611):1407-10.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Biology 156-29, California Institute of Technology, 1201 California Boulevard, Pasadena, CA 91125, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12610309" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Body Weight
;
Crosses, Genetic
;
Drosophila melanogaster/genetics/growth & development/*physiology
;
Ecdysone/biosynthesis/*physiology
;
Ecdysterone/administration & dosage/pharmacology
;
Female
;
Fertility
;
Genes, Insect
;
Ligands
;
*Longevity
;
Male
;
Mutation
;
Oxidative Stress
;
Phototropism
;
Receptors, Steroid/genetics/*physiology
;
Starvation
;
Temperature
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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