Publication Date:
2003-08-30
Description:
Plant disease-resistance (R) proteins are thought to function as receptors for ligands produced directly or indirectly by pathogen avirulence (Avr) proteins. The biochemical functions of most Avr proteins are unknown, and the mechanisms by which they activate R proteins have not been determined. In Arabidopsis, resistance to Pseudomonas syringae strains expressing AvrPphB requires RPS5, a member of the class of R proteins that have a predicted nucleotide-binding site and leucine-rich repeats, and PBS1, a protein kinase. AvrPphB was found to proteolytically cleave PBS1, and this cleavage was required for RPS5-mediated resistance, which indicates that AvrPphB is detected indirectly via its enzymatic activity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shao, Feng -- Golstein, Catherine -- Ade, Jules -- Stoutemyer, Mark -- Dixon, Jack E -- Innes, Roger W -- DK18849/DK/NIDDK NIH HHS/ -- GM46451/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2003 Aug 29;301(5637):1230-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biological Chemistry, Medical School and Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12947197" target="_blank"〉PubMed〈/a〉
Keywords:
Amino Acid Sequence
;
Arabidopsis/genetics/*metabolism/microbiology
;
Arabidopsis Proteins/chemistry/genetics/*metabolism
;
Bacterial Proteins/chemistry/genetics/*metabolism
;
Carrier Proteins/genetics/metabolism
;
Cell Line
;
Cysteine Endopeptidases/chemistry/genetics/*metabolism
;
Genes, Bacterial
;
Genes, Plant
;
Genetic Complementation Test
;
Humans
;
Models, Biological
;
Molecular Sequence Data
;
Mutation
;
Phosphorylation
;
Plant Diseases/*microbiology
;
Plant Extracts/metabolism
;
Plant Proteins/genetics/metabolism
;
Plants, Genetically Modified
;
Precipitin Tests
;
Protein Structure, Tertiary
;
Protein-Serine-Threonine Kinases/chemistry/genetics/*metabolism
;
Pseudomonas/*metabolism
;
Recombinant Proteins/metabolism
;
Tobacco/genetics/metabolism
;
Transformation, Genetic
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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