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  • Engineering Design.  (2)
  • Apoptosis Ultrastructure TUNEL labeling Prostate Castration Proteases Rat (Sprague Dawley)  (1)
  • Characterization  (1)
  • 1
    Online Resource
    Online Resource
    Slope Stochastic Dynamics (2022)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Geotechnical engineering. ; Natural disasters. ; Engineering design. ; Civil engineering. ; Sustainability. ; Geotechnical Engineering and Applied Earth Sciences. ; Natural Hazards. ; Engineering Design. ; Civil Engineering. ; Sustainability.
    Abstract: This book provides a new framework for analysis of slope nonlinear stochastic seismic dynamic response based on the new theoretical tool of stochastic dynamics. The coupling effects of uncertainty of geological parameters, strong dynamic nonlinearity, and randomness of ground motion are considered in the process of the seismic dynamic stability assessment of slope. In this book, an intensity frequency non-stationary stochastic ground motion model based on time-domain stochastic process description is preliminarily established to characterize the randomness of earthquakes. The spatial distribution random field model of geotechnical parameters is established to describe the time-space variability of geotechnical parameters. Based on the basic theory of stochastic dynamics, the seismic stability performance evaluation method of slope is established. The slope seismic dynamic model test based on large complex shaking table is performed to verify and modify the proposed framework and method. This book sheds new light on the development of nonlinear seismic stochastic dynamics and seismic design of slope engineering. .
    Type of Medium: Online Resource
    Pages: XXII, 155 p. 86 illus., 79 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811696978
    URL: https://doi.org/10.1007/978-981-16-9697-8
    DOI: 10.1007/978-981-16-9697-8
    DDC: 624.151
    Language: English
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  • 2
    Online Resource
    Online Resource
    Guidelines for Probabilistic Performance-Based Seismic Design and Assessment of Slope Engineering (2023)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Geotechnical engineering. ; Natural disasters. ; Engineering design. ; Engineering geology. ; Sustainability. ; Geotechnical Engineering and Applied Earth Sciences. ; Natural Hazards. ; Engineering Design. ; Geoengineering. ; Sustainability.
    Description / Table of Contents: Introduction -- Terms and Notations -- Performance-based Seismic Design of Slope -- Seismic Ground Motion Excitations for Slope Seismic Dynamic Performance Design and Assessment -- Deterministic Analysis Methods for Slope Seismic Dynamic Response -- Probabilistic Performance-based Seismic Design and Assessment for Slope Engineering -- Case Study -- Conclusions and Prospects.
    Abstract: This book provides a new design and evaluation framework based on slope Stochastic Dynamics theory to probabilistic seismic performance for slope engineering. For the seismic dynamic stability safety of slope, it shifts from deterministic seismic dynamic analysis to quantitative analysis based on nonlinear stochastic dynamics, that is, from qualitative to the description of stochasticity of earthquake excitation that meet the needs in related design specification and establish a performance standard. In the nonlinear dynamic time history analysis of slope subjected to seismic ground motion, the term “randomness” is used to express the uncertainty in the intensity and frequency of earthquake excitation for slope engineering dynamic seismic performance. It mainly includes seismic design fortification standard, corresponding ground motion excitation, performance index threshold, and slope deterministic nonlinear seismic dynamic response. Even more than that, the seismic dynamic large deformation approaches of the whole process and comprehensive analysis for flow analysis after slope instability failure. Eventually, the probabilistic seismic dynamic performance of the slope engineering will be characterized by nonlinear dynamic reliability.
    Type of Medium: Online Resource
    Pages: XVII, 134 p. 51 illus., 46 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789811991837
    URL: https://doi.org/10.1007/978-981-19-9183-7
    DOI: 10.1007/978-981-19-9183-7
    DDC: 624.151
    Language: English
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  • 3
    Electronic Resource
    Electronic Resource
    Ultrastructural and biochemical observations on the early changes in apoptotic epithelial cells of the rat prostate induced by castration (1999)
    Springer
    Cell & tissue research 298 (1999), S. 123-136 
    Details
    ISSN: 1432-0878
    Keywords: Apoptosis Ultrastructure TUNEL labeling Prostate Castration Proteases Rat (Sprague Dawley)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract. The present study describes the sequential ultrastructural changes in the apoptotic cells of the rat ventral and dorsal prostates during the early period of 1–3 days postcastration. The major morphological changes include: (1) condensation of heterochromatin along the nuclear envelope and fragmentation into crescent-shaped micronuclei; (2) formation of membrane-bound cytoplasmic spherical bodies, which contain various organelles and micronuclei, within the apoptotic cells; (3) formation of non-membrane-bound autolytic vacuoles by autolysis of cytoplasm; (4) focal rupture of outer mitochondrial membrane; and (5) phagocytosis of the fragmented cytoplasmic spherical bodies and apoptotic cells by macrophages. The occurrence of both cytoplasmic apoptotic bodies and autolytic vacuoles in apoptotic cells suggests that the cytoplasm of the apoptotic cells could be destroyed by different means. The responsiveness of different prostatic lobes to androgen withdrawal and the time course of the transitory apoptotic activity in different lobes were analyzed by counting the indices of the TUNEL-labeled apoptotic cells against the postcastration periods. The results showed that the ventral lobe responded more rapidly to castration than the lateral and dorsal lobes. The dorsal lobe was the slowest in response to castration among the three lobes. Analysis of protease activities by zymography has identified two Ca2+-independent proteases of apparent MW 20 and 24 kDa (expressed in both ventral and dorsolateral lobes), and one Ca2+-dependent protease of MW 66.5 kDa (expressed only in the dorsolateral lobe) which became activated at day 3 postcastration. Their expression patterns were different from that of CPP-3 in the castrated prostates, suggesting that the activated proteases were enzymes other than CPP-3. The association of their highest activities with the maximum apoptotic activity at day 3 postcastration and also their loss of activity at day 15 suggest that these protease activities might be related to apoptosis or glandular involution.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004419900057
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  • 4
    Electronic Resource
    Electronic Resource
    Characterization of a wall-jet electrode/flow-injection analysis system (1994)
    Weinheim : Wiley-Blackwell
    Electroanalysis 6 (1994), S. 1077-1082 
    Details
    ISSN: 1040-0397
    Keywords: Detector ; Wall-jet electrode ; Flow-injection analysis ; Characterization ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A “wall-jet” electrode (WJE) was studied as an electrochemical deteaor for flow-injection analysis (FIA). Mathematical expressions were obtained for the peak current responses of the electrode, both for an uncoiled open tubular conduit and also in the presence of a packed-bed reactor between the injection valve and detector. The derived relationships between peak current and volumetric flow rate, and injected sample volume and concentration of the analyte were verified by using the ferricyanide ion and hydrogen peroxide as test samples. In general, theory and experiment were in good agreement although a discrepancy in the volumetric flow rate dependence of the peak current was observed in the presence of a packed-bed reactor.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/elan.1140061127
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