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  • 1
    Electronic Resource
    Electronic Resource
    Modulation of neuronal responses tol-glutamate inAplysia (1984)
    Springer
    Cellular and molecular neurobiology 4 (1984), S. 91-95 
    Details
    ISSN: 1573-6830
    Keywords: potentiation ; neurons ; Aplysia ; L-glutamate ; L-aspartate ; reuptake ; modulation ; interaction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary 1. Potentiation of the excitatory response to L-glutamate (Glu) by L-aspartate (Asp), similar to that which has been described at the crustacean neuromuscular junction, is observed inAplysia neurons which are glutamate sensitive. 2. Potentiation of the inhibitory responses to ionophoretically applied Glu in neurons preconditioned with Asp permits experiments which serve to differentiate among four hypotheses previously proposed to explain the underlying mechanism of the phenomenon. 3. The potentiation is inhibited by cooling (Q 10 = 1.3 ± 0.2) and is blocked in Na+-free seawater, where the response to Glu applied alone is increased in both amplitude and duration. 4. These results are most consistent with the view that Glu is normally removed from the extracellular medium through an active reuptake process which is Na+ dependent, is slightly temperature sensitive, and may be blocked by Asp.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00710945
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  • 2
    Electronic Resource
    Electronic Resource
    Kinetics of acetylcholine-activated cation channel blockade by the calcium antagonist D-600 inAplysia neurons (1983)
    Springer
    Cellular and molecular neurobiology 3 (1983), S. 329-344 
    Details
    ISSN: 1573-6830
    Keywords: D-600 ; acetylcholine receptors ; Aplysia ; ion channels ; voltage clamp
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary 1. The effects of the calcium channel blocker D-600 on the cation channels activated by acetylcholine (ACh) was studied in voltage-clampedAplysia neurons by voltage-jump relaxation analysis. 2. D-600 blocked the steady-state ACh current in a highly voltage-dependent manner, the degree of antagonism increasing with membrane hyperpolarization. 3. In the presence of D-600 the current relaxations following hyperpolarizing command steps became biphasic. The time constants of ACh-induced current relaxations (τ f), which approximate the mean channel lifetime, were reduced in a voltage-dependent manner, the degree of reduction ofτ f increasing with increasing membrane potential. 4. In addition to the acceleration ofτ f, a slow, inverse kinetic component (τ s) of the relaxation appeared in the presence of D-600. The rate of this inverse kinetic component was accelerated either by increasing the agonist or antagonist dose or by increasing the membrane potential. 5. These results suggest that D-600 acts to antagonize the acetylcholine response through a blockade of the open state of the transmitter-activated cation channel. Possible kinetic schemes for this interaction are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00734714
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  • 3
    Electronic Resource
    Electronic Resource
    A study of the cholinolytic actions of strychnine using the technique of concentration jump relaxation analysis (1984)
    Springer
    Cellular and molecular neurobiology 4 (1984), S. 263-271 
    Details
    ISSN: 1573-6830
    Keywords: strychnine ; acetylcholine receptors ; Aplysia ; relaxation analysis ; isolated neurons
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary 1. The blocking actions of strychnine on excitatory acetylcholine (ACh) responses in isolated, voltage clampedAplysia neuronal cell bodies has been studied using a rapid drug application technique. 2. Rapid microperfusion of strychnine (10–50µM) produced a reduction of the steady-state ACh-induced inward current inAplysia neurons which decayed exponentially with a highly dose-dependent time constant. At the cessation of strychnine perfusion the ACh-induced current recovered to its original value with an exponential time course which was not sensitive to the dose of strychnine previously applied. 3. The calculated association (k 1) and dissociation (k -1) constants for a pseudo-first-order reaction between strychnine and its binding site werek 1 = 1.2 × 104 M −1 · sec−1 andk -1 = 0.12 sec−1 (K D = 1 × 10−5 M −1). 4. These results demonstrate that concentration jump relaxation experiments can be performed on isolated neurons for the study of voltage-independent antagonists by the use of rapid microperfusion systems and provide the first direct estimates to date of the rate constants of the cholinolytic effect of strychnine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00733589
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