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  • 1
    Electronic Resource
    Electronic Resource
    Organ-specific crystalline structures of ferritin cores inβ-thalassemia/hemoglobin E (1991)
    Springer
    BioMetals 4 (1991), S. 162-165 
    Details
    ISSN: 1572-8773
    Keywords: Ferritin ; Thalassemia ; Ferrihydrite ; Crystallinity ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Summary The cores of ferritins isolated from different organs of human subjects withβ-thalassemia/hemoglobin E (β-thal/HbE) disease have different size distributions and crystallinities depending on the source organ. These patients have not been treated by hypertransfusion regimen or iron chelation therapy.β-Thal/HbE spleens and livers yield ferritin cores which are less crystalline than those isolated from normal spleens and livers, reflecting the more rapid deposition of iron in the diseased state. Ferritins isolated from the hearts and pancreases ofβ-thal/HbE subjects were found to have larger, more crystalline cores than those from theβ-thal/HbE livers and spleens, possibly as a consequence of the role of the heart and pancreas as long-term iron deposition sites in this iron overload pathology.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01141308
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  • 2
    Electronic Resource
    Electronic Resource
    Biospeciation, by potentiometry and computer simulation, of Sm-EDTMP, a bone tumor palliative agent (1996)
    Springer
    BioMetals 9 (1996), S. 351-361 
    Details
    ISSN: 1572-8773
    Keywords: EDTMP ; formation constants ; protonation constants ; samarium ; speciation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract 153Sm-EDTMP (ethylenediaminetetra(methylenephosphonic) acid) is of considerable interest as a bone therapeutic radiopharmaceutical but its properties in solution are not yet well characterized. The protonation constants of EDTMP and the formation constants of the complexes of Sm-EDTMP have accordingly been measured potentiometrically by glass electrode titrations at 25°C in 0.15 M NaCl. Six protonation constants (log β011 = 9.638, log β012 = 17.330, log β013 = 23.597, log β014 = 28.636, log β015 = 31.501, log β016 = 32.624) and the formation constants of the [Sm(EDTMP)H-1]6- (log β11-1 = 4.865), [SmEDTMP]5- (log β110 = 12.018), [Sm(EDTMP)H]4- (log β111 = 17.892) and [Sm(EDTMP)H2]3- (log β112 = 23.437) complexes were determined. Computer simulations indicate that the [SmEDTMP]5- and the hydroxy [Sm(EDTMP)H-1]6- species are the major Sm(III) complexes formed in blood plasma, which explains the high degree of localization in the kidney and urine observed in biodistribution studies. Calcium ions are probably the maior competitor for EDTMP in blood plasma. As the presence of secondary skeletal metastases results in a high rate of bone turnover, it is possible that the high concentration of calcium at these sites encourages localization of 153Sm-EDTMP.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00140604
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  • 3
    Electronic Resource
    Electronic Resource
    Calcium biomineralization in the radular teeth of the chiton, Acanthopleura hirtosa (1992)
    Springer
    Calcified tissue international 51 (1992), S. 78-82 
    Details
    ISSN: 1432-0827
    Keywords: Molluscs ; Chiton radula ; Apatite ; Organic matrix
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary A method has been devised for isolating the calcium biomineral from the iron biominerals and organic components present in the major lateral teeth of the chiton Acanthopleura hirtosa. Fourier-transform infrared spectroscopy of the calcium biomineral indicated that it was an apatite material containing carbonate and fluoride ions. Carbonate was not found to be present as a separate phase. The apatite was further separated into low and high density fractions, both of which showed crystallinity intermediate between that of bovine tibia cortical bone and human tooth enamel, as indicated by powder X-ray diffraction analysis. The calcified region of the major lateral teeth was also studied in situ using transmission electron microscopy and electron diffraction analysis, revealing a close spatial relationship between the mineral apatite phase and underlying organic matrix. It is suggested that the architectural arrangement of apatite biomineral and fibrous organic constituents imparts specialized mechanical properties to the tooth making it ideally suited for the task of obtaining food from hard surfaces.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00296222
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