ISSN:
1476-5535
Keywords:
Rebeccamycin
;
Saccharothrix aerocolonigenes
;
Carbon catabolite regulation
;
Antitumor antibiotic
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Process Engineering, Biotechnology, Nutrition Technology
Notes:
Summary A new antitumor antibiotic named rebeccamycin was isolated from fermentations of an actinomycete,Saccharothrix aerocolonigenes. A defined medium was developed to study the regulation of synthesis of rebeccamycin byS. aerocolonigenes. In glucose medium formation of rebeccamycin was detected only after glucose was depleted. Examination of eleven different carbon sources revealed that carbon catabolite regulation is a major control mechanism for rebeccamycin production.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01569794
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