Publication Date:
1995-09-22
Description:
Description of the genetic structure of malaria parasite populations is central to an understanding of the spread of multiple-locus drug and vaccine resistance. The Plasmodium falciparum mating patterns from madang, Papua New Guinea, where intense transmission of malaria occurs, are described here. A high degree of inbreeding occurs in the absence of detectable linkage disequilibrium. This contrasts with other studies, indicating that the genetic structure of malaria parasite populations is neither clonal nor panmictic but will vary according to the transmission characteristics of the region.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Paul, R E -- Packer, M J -- Walmsley, M -- Lagog, M -- Ranford-Cartwright, L C -- Paru, R -- Day, K P -- Wellcome Trust/United Kingdom -- New York, N.Y. -- Science. 1995 Sep 22;269(5231):1709-11.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Zoology, University of Oxford, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7569897" target="_blank"〉PubMed〈/a〉
Keywords:
Alleles
;
Animals
;
Anopheles/parasitology
;
Antimalarials/pharmacology
;
Base Sequence
;
Drug Resistance/genetics
;
Female
;
*Genes, Protozoan
;
Genetic Variation
;
Genotype
;
Heterozygote
;
Humans
;
Inbreeding
;
Insect Vectors/parasitology
;
Linkage Disequilibrium
;
Malaria, Falciparum/*parasitology/transmission
;
Male
;
Merozoite Surface Protein 1
;
Molecular Sequence Data
;
Papua New Guinea
;
Plasmodium falciparum/drug effects/*genetics/physiology
;
Protein Precursors/genetics
;
Protozoan Proteins/genetics
;
Reproduction
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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