Publication Date:
2006-05-06
Description:
B cells recognize foreign antigens by virtue of cell surface immunoglobulin receptors and are most effectively activated by membrane-bound ligands. Here, we show that in the early stages of this process, B cells exhibit a two-phase response in which they first spread over the antigen-bearing membrane and then contract, thereby collecting bound antigen into a central aggregate. The extent of this response, which is both signaling- and actin-dependent, determines the quantity of antigen accumulated and hence the degree of B cell activation. Brownian dynamic simulations reproduce essential features of the antigen collection process and suggest a possible basis for affinity discrimination. We propose that dynamic spreading is an important step of the immune response.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fleire, S J -- Goldman, J P -- Carrasco, Y R -- Weber, M -- Bray, D -- Batista, F D -- G64713/PHS HHS/ -- New York, N.Y. -- Science. 2006 May 5;312(5774):738-41.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Lymphocyte Interaction Laboratory, London Research Institute, Cancer Research UK, 44 Lincoln's Inn Fields, London, WC2A 3PX, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16675699" target="_blank"〉PubMed〈/a〉
Keywords:
Actins/physiology
;
Algorithms
;
Animals
;
Antibody Affinity
;
Antigen Presentation
;
Antigens, Surface/*immunology
;
B-Lymphocytes/*immunology/*physiology
;
Cell Shape
;
Computer Simulation
;
Flow Cytometry
;
Ligands
;
Lipid Bilayers
;
*Lymphocyte Activation
;
Mice
;
Mice, Transgenic
;
Microscopy, Fluorescence
;
Models, Immunological
;
Muramidase/immunology
;
Receptors, Antigen, B-Cell/*immunology/metabolism
;
Recombinant Fusion Proteins/immunology
;
Signal Transduction
;
Stochastic Processes
;
T-Lymphocytes/immunology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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