Publication Date:
1991-05-03
Description:
The circumsporozoite (CS) protein has been the target for development of malaria sporozoite vaccines for a decade. However, immunization with subunit vaccines based on the CS protein has never given the complete protection found after immunization with irradiated sporozoites. BALB/c mice immunized with irradiated Plasmodium yoelii sporozoites produced antibodies and cytotoxic T cells against a 140-kilodalton protein, sporozoite surface protein 2 (SSP2). Mice immunized with P815 cells that had been transfected with either SSP2 or CS genes were partially protected, and those immunized with a mixture of SSP2 and CS transfectants were completely protected against malaria. These studies emphasize the importance of vaccine delivery systems in achieving protection and define a multi-antigen sporozoite vaccine.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Khusmith, S -- Charoenvit, Y -- Kumar, S -- Sedegah, M -- Beaudoin, R L -- Hoffman, S L -- New York, N.Y. -- Science. 1991 May 3;252(5006):715-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Malaria Program, Naval Medical Research Institute, Bethesda, MD 20889.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1827210" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Antibodies, Monoclonal/immunology
;
Antibodies, Protozoan/immunology
;
Antigens, Protozoan/genetics/*immunology
;
Immunization
;
Malaria/*prevention & control
;
Mice
;
Mice, Inbred BALB C
;
Molecular Weight
;
Plasmodium yoelii/*immunology
;
Protozoan Proteins/genetics/*immunology
;
*Protozoan Vaccines
;
T-Lymphocytes, Cytotoxic/immunology
;
T-Lymphocytes, Helper-Inducer/immunology
;
T-Lymphocytes, Regulatory/immunology
;
Transfection
;
*Vaccination
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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