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    Thymic origin of intestinal alphabeta T cells revealed by fate mapping of RORgammat+ cells (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-07-13
    Description: Intestinal intraepithelial T lymphocytes (IELs) are likely to play a key role in host mucosal immunity and, unlike other T cells, have been proposed to differentiate from local precursors rather than from thymocytes. We show here that IELs expressing the alphabeta T cell receptor are derived from precursors that express RORgammat, an orphan nuclear hormone receptor detected only in immature CD4+CD8+ thymocytes, fetal lymphoid tissue-inducer (LTi) cells, and LTi-like cells in cryptopatches within the adult intestinal lamina propria. Using cell fate mapping, we found that all intestinal alphabeta T cells are progeny of CD4+CD8+ thymocytes, indicating that the adult intestine is not a significant site for alphabeta T cell development. Our results suggest that intestinal RORgammat+ cells are local organizers of mucosal lymphoid tissue.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Eberl, Gerard -- Littman, Dan R -- New York, N.Y. -- Science. 2004 Jul 9;305(5681):248-51.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15247480" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antigens, CD4/analysis ; Antigens, CD8/analysis ; Cell Lineage ; DNA-Binding Proteins/metabolism ; Hematopoietic Stem Cells/immunology/physiology ; Immunity, Mucosal ; Intestinal Mucosa/cytology/*immunology ; Lymphoid Tissue/embryology/immunology ; Mice ; Mice, Transgenic ; Nuclear Receptor Subfamily 1, Group F, Member 3 ; Receptors, Antigen, T-Cell, alpha-beta/*analysis/genetics ; Receptors, Antigen, T-Cell, gamma-delta/analysis/genetics ; Receptors, Retinoic Acid/genetics/*metabolism ; Receptors, Thyroid Hormone/genetics/*metabolism ; T-Lymphocyte Subsets/cytology/*immunology ; T-Lymphocytes/cytology/*immunology ; Thymus Gland/cytology/*immunology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    A subset of CD4+ thymocytes selected by MHC class I molecules (1994)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1994-03-25
    Description: To complete their maturation, most immature thymocytes depend on the simultaneous engagement of their antigen receptor [alpha beta T cell receptor (TCR)] and their CD4 or CD8 coreceptors with major histocompatibility complex class II or I ligands, respectively. However, a normal subset of mature alpha beta TCR+ thymocytes did not follow these rules. These thymocytes expressed NK1.1 and a restricted set of alpha beta TCRs that are intrinsically class I-reactive because their positive selection was class I-dependent but CD8-independent. These cells were CD4+ and CD4-8- but never CD8+, because the presence of CD8 caused negative selection. Thus, neither CD4 nor CD8 contributes signals that direct their maturation into the CD4+ and CD4-8- lineages.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bendelac, A -- Killeen, N -- Littman, D R -- Schwartz, R H -- New York, N.Y. -- Science. 1994 Mar 25;263(5154):1774-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7907820" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antigens/analysis ; Antigens, CD4/analysis ; Antigens, CD8/analysis ; Antigens, Ly ; Antigens, Surface ; CD4-Positive T-Lymphocytes/cytology/*immunology ; Female ; Histocompatibility Antigens Class I/*physiology ; Lectins, C-Type ; Ligands ; Lymphocyte Activation ; Male ; Mice ; Mice, Inbred C57BL ; NK Cell Lectin-Like Receptor Subfamily B ; Phenotype ; Proteins/analysis ; Receptors, Antigen, T-Cell, alpha-beta/analysis/*physiology ; T-Lymphocyte Subsets/cytology/*immunology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
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    PAPER CURRENT
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