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  • 1
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    Preferential localization of effector memory cells in nonlymphoid tissue (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-03-27
    Description: Many intracellular pathogens infect a broad range of host tissues, but the importance of T cells for immunity in these sites is unclear because most of our understanding of antimicrobial T cell responses comes from analyses of lymphoid tissue. Here, we show that in response to viral or bacterial infection, antigen-specific CD8 T cells migrated to nonlymphoid tissues and were present as long-lived memory cells. Strikingly, CD8 memory T cells isolated from nonlymphoid tissues exhibited effector levels of lytic activity directly ex vivo, in contrast to their splenic counterparts. These results point to the existence of a population of extralymphoid effector memory T cells poised for immediate response to infection.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Masopust, D -- Vezys, V -- Marzo, A L -- Lefrancois, L -- AI41576/AI/NIAID NIH HHS/ -- DK45260/DK/NIDDK NIH HHS/ -- T32-AI07080/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 2001 Mar 23;291(5512):2413-7. Epub 2001 Mar 1.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Immunology, Department of Medicine, University of Connecticut Health Center, Farmington, CT 06030, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11264538" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; CD8-Positive T-Lymphocytes/*immunology ; Cell Movement ; Cells, Cultured ; Flow Cytometry ; H-2 Antigens/immunology ; *Immunologic Memory ; Intestine, Small/immunology ; Listeria monocytogenes/genetics/immunology ; Listeriosis/*immunology ; Liver/immunology ; Lung/immunology ; Lymphocyte Activation ; Lymphoid Tissue/immunology ; Mice ; Mice, Inbred C57BL ; Ovalbumin/immunology ; Phenotype ; Rhabdoviridae Infections/*immunology ; T-Lymphocyte Subsets/*immunology ; Vesicular stomatitis Indiana virus/immunology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    In situ imaging of the endogenous CD8 T cell response to infection (2007)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2007-10-06
    Description: Mounting a protective immune response is critically dependent on the orchestrated movement of cells within lymphoid organs. We report here the visualization, using major histocompatability complex class I tetramers, of the CD8-positive (CD8) T cell response in the spleens of mice to Listeria monocytogenes infection. A multistage pathway was revealed that included initial activation at the borders of the B and T cell zones followed by cluster formation with antigenpresenting cells leading to CD8 T cell exit to the red pulp via bridging channels. Strikingly, many memory CD8 T cells localized to the B cell zones and, when challenged, underwent rapid migration to the T cell zones where proliferation occurred, followed by egress via bridging channels in parallel with the primary response. Thus, the ability to track endogenous immune responses has uncovered both distinct and overlapping mechanisms and anatomical locations driving primary and secondary immune responses.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2846662/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2846662/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Khanna, Kamal M -- McNamara, Jeffery T -- Lefrancois, Leo -- AI41576/AI/NIAID NIH HHS/ -- AI56172/AI/NIAID NIH HHS/ -- DRG-1886-05/PHS HHS/ -- P01 AI056172/AI/NIAID NIH HHS/ -- P01 AI056172-05/AI/NIAID NIH HHS/ -- R01 AI041576/AI/NIAID NIH HHS/ -- R01 AI041576-06/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 2007 Oct 5;318(5847):116-20.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Immunology, University of Connecticut, Farmington, CT 06030, U.S.A.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17916739" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antigen-Presenting Cells/immunology ; Antigens, CD/analysis ; Antigens, CD8/analysis ; B-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/cytology/*immunology/physiology ; Cell Movement ; Dendritic Cells/immunology/physiology ; Fluorescent Dyes ; Histocompatibility Antigens Class I ; *Immunologic Memory ; Kinetics ; Listeria monocytogenes/*immunology ; Listeriosis/*immunology ; Lymphocyte Activation ; Mice ; Mice, Inbred C57BL ; Microscopy, Confocal ; Receptors, Antigen, T-Cell/analysis ; Spleen/cytology/*immunology ; Staining and Labeling ; T-Lymphocyte Subsets/cytology/immunology/physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
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    PAPER CURRENT
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