ISSN:
1573-4935
Schlagwort(e):
Antigenic determinant
;
Autophosphorylation sites
;
Conformation-specific antibody
;
EGF receptor
;
Receptor tyrosine kinase
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Biologie
,
Chemie und Pharmazie
Notizen:
Abstract Phosphorylation-induced conformational changes have been well documented with different receptor tyrosine kinases. However, the susceptible epitopes and the tyrosine residue(s) involved in particular structural alteration mostly remain to be determined. Using a conformation-specific anti-peptide antibody, we have not only identified one such domain in the C-terminal tail of the EGF receptor but also identified the phosphate acceptor sites that are involved in the conformational change.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1023/A:1020260105524
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