Publication Date:
2008-10-04
Description:
Host-microbe symbioses play a critical role in the evolution of biological diversity and complexity. In a notably intricate system, southern pine beetles use symbiotic fungi to help overcome host-tree defenses and to provide nutrition for their larvae. We show that this beetle-fungal mutualism is chemically mediated by a bacterially produced polyunsaturated peroxide. The molecule's selective toxicity toward the beetle's fungal antagonist, combined with the prevalence and localization of its bacterial source, indicates an insect-microbe association that is both mutualistic and coevolved. This unexpected finding in a well-studied system indicates that mutualistic associations between insects and antibiotic-producing bacteria are more common than currently recognized and that identifying their small-molecule mediators can provide a powerful search strategy for therapeutically useful antimicrobial compounds.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2761720/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2761720/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Scott, Jarrod J -- Oh, Dong-Chan -- Yuceer, M Cetin -- Klepzig, Kier D -- Clardy, Jon -- Currie, Cameron R -- R01 CA024487/CA/NCI NIH HHS/ -- R01 CA024487-29/CA/NCI NIH HHS/ -- R01 CA024487-30/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 2008 Oct 3;322(5898):63. doi: 10.1126/science.1160423.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Bacteriology, University of Wisconsin-Madison, WI 53706, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18832638" target="_blank"〉PubMed〈/a〉
Keywords:
Acetates/chemistry/*metabolism/pharmacology
;
Actinobacteria/isolation & purification/*metabolism
;
Agaricus
;
Animals
;
Antibiosis
;
Antifungal Agents/*biosynthesis/chemistry/pharmacology
;
Ascomycota/*physiology
;
Basidiomycota/*physiology
;
Beetles/growth & development/*microbiology/physiology
;
Biological Evolution
;
Larva/growth & development/microbiology
;
Peroxides/chemistry/*metabolism/pharmacology
;
Pinus/microbiology
;
Symbiosis
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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