Publication Date:
2003-10-04
Description:
Endocannabinoids have paradoxical effects on the mammalian nervous system: Sometimes they block neuronal excitability and other times they augment it. In their Perspective, Mechoulam and Lichtman discuss new work (Marsicano et al.) showing that activation of the cannabinoid receptor CB1 by the endocannabinoid anandamide protects against excitotoxic damage in a mouse model of kainic acid-induced epilepsy.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mechoulam, R -- Lichtman, A H -- New York, N.Y. -- Science. 2003 Oct 3;302(5642):65-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Medicinal Chemistry and Natural Products, Medical Faculty, Hebrew University, Jerusalem 91120, Israel. mechou@cc.huji.ac.il〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14526067" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Anticonvulsants/metabolism
;
Arachidonic Acids/*metabolism/pharmacology/therapeutic use
;
Brain/drug effects/*metabolism
;
Brain Diseases/drug therapy
;
Cannabidiol/pharmacology/therapeutic use
;
Cannabinoid Receptor Modulators
;
Cannabinoids/*metabolism/pharmacology/therapeutic use
;
Convulsants/metabolism
;
Dronabinol/analogs & derivatives/pharmacology/therapeutic use
;
Endocannabinoids
;
Epilepsy/drug therapy/*metabolism
;
Excitatory Amino Acid Agonists/pharmacology
;
Excitatory Amino Acid Antagonists/pharmacology/therapeutic use
;
Glutamic Acid/metabolism
;
Glycerides/metabolism/pharmacology/therapeutic use
;
Humans
;
Kainic Acid/pharmacology
;
Mice
;
Neurons/drug effects/metabolism
;
Neuroprotective Agents/*metabolism
;
Polyunsaturated Alkamides
;
Rats
;
Receptors, Cannabinoid
;
Receptors, Drug/agonists/antagonists & inhibitors/genetics/*metabolism
;
Signal Transduction
;
gamma-Aminobutyric Acid/metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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