Publication Date:
1979-06-22
Description:
A 43,000-dalton polypeptide has been isolated from the high-molecular-weight disulfide-rich fraction of the water-insoluble protein of human cataractous lenses. On the basis of immunochemical reactivity and fluorescent antibody binding, this polypeptide is localized in the membrane region of the lens cell. This observation suggests an interaction between the soluble lens proteins and membrane-associated polypeptides in the formation of large protein aggregates which may cause cataract.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Spector, A -- Garner, M H -- Garner, W H -- Roy, D -- Farnsworth, P -- Shyne, S -- New York, N.Y. -- Science. 1979 Jun 22;204(4399):1323-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/377484" target="_blank"〉PubMed〈/a〉
Keywords:
Antibody Specificity
;
Cataract/*metabolism
;
Crystallins/immunology/*metabolism
;
Fluorescent Antibody Technique
;
Humans
;
Membrane Proteins/*metabolism
;
Molecular Weight
;
Protein Binding
;
Solubility
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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