Publication Date:
1996-07-12
Description:
The mechanisms underlying the profound suppression of cell-mediated immunity (CMI) accompanying measles are unclear. Interleukin-12 (IL-12), derived principally from monocytes and macrophages, is critical for the generation of CMI. Measles virus (MV) infection of primary human monocytes specifically down-regulated IL-12 production. Cross-linking of CD46, a complement regulatory protein that is the cellular receptor for MV, with antibody or with the complement activation product C3b similarly inhibited monocyte IL-12 production, providing a plausible mechanism for MV-induced immunosuppression. CD46 provides a regulatory link between the complement system and cellular immune responses.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Karp, C L -- Wysocka, M -- Wahl, L M -- Ahearn, J M -- Cuomo, P J -- Sherry, B -- Trinchieri, G -- Griffin, D E -- AI01223/AI/NIAID NIH HHS/ -- AI23047/AI/NIAID NIH HHS/ -- AI35149/AI/NIAID NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1996 Jul 12;273(5272):228-31.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8662504" target="_blank"〉PubMed〈/a〉
Keywords:
Antibodies, Monoclonal
;
Antigens, CD/immunology/*physiology
;
Antigens, CD46
;
Binding Sites
;
Cells, Cultured
;
Chemokines/biosynthesis
;
Complement C3b/immunology/physiology
;
Cytokines/biosynthesis
;
Down-Regulation
;
Humans
;
*Immune Tolerance
;
Interleukin-10/physiology
;
Interleukin-12/*biosynthesis
;
Measles virus/*immunology/metabolism
;
Membrane Glycoproteins/immunology/*physiology
;
Monocytes/*immunology/*virology
;
Receptors, Virus/immunology/*physiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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