ISSN:
1434-193X
Keywords:
Antibiotics
;
Asymmetric synthesis
;
β-Lactams
;
Michael additions
;
Multicomponent reactions
;
Chemistry
;
General Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Lithium dialkylcuprates react either in a sequential one-pot or in a domino “three-component” fashion with chiral Michael acceptors, like Oppolzer's N-enoyl-2,10-camphorsultams 7 and 11 or ‘Evans’ N-enoyl-4-phenyl-1,3-oxazolidin-2-ones 8 and 13, and N-(methoxycarbonylmethylidene)(4-methoxyphenyl)amine 9 to afford the corresponding cis-3-alkyl-4-methoxycarbonyl-1-(4-methoxyphenyl)azetidin-2-ones 10, 14-15 in overall yields of 40-67% and enantiomeric excesses of 91-99%.
Type of Medium:
Electronic Resource
Permalink