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Aplysianin-A, an antibacterial and antineoplastic glycoprotein in the albumen gland of a sea hare,Aplysia kurodai (1986)

Kamiya, H. ; Muramoto, K. ; Yamazaki, M.

Springer

Cellular and molecular life sciences 42 (1986), S. 1065-1067

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ISSN: 1420-9071

Keywords: Antibacterial factor ; antineoplastic factor ; Aplysia ; opisthobranch ; albumen gland

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Medicine

Notes: Summary Aplysianin-A, an antibacterial and antineoplastic factor in the albumen gland of the sea hareAplysia kurodai, was isolated. It had a molecular weight of approximately 320 kD and consisted of subunits with a molecular weight of 85 kD. It contained 9.8% neutral sugar. Aplysianin A showed 50% inhibition ofBacillus subtilis growth at a concentration of 4 μg protein/ml and 50% lysis of murine MM46 tumor cells at 14 ng protein/ml. A partial identity of antigenic specificity of the purified specimen with an antineoplastic factor fromAplysia eggs was observed in immunodiffusion tests.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01940736

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