Publication Date:
1978-08-18
Description:
In weanling mice treated with pharmacologic doses of aminophylline, the concentrations of adenosine 3',5'-monophosphate and guanosine 3',5'-monophosphate in the brain increased 44 and 36 percent, respectively, and the cerebral metabolic rate was three times that in controls. In neonatal mice, therapeutic doses of aminophylline greatly decreased the rate of anoxic survival in vivo and the duration of gasping of the isolated head. The findings suggest caution in the use of this drug and other methylxanthines in hypoxic human newborns.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Thurston, J H -- Hauhard, R E -- Dirgo, J A -- New York, N.Y. -- Science. 1978 Aug 18;201(4356):649-51.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/209541" target="_blank"〉PubMed〈/a〉
Keywords:
Adenine Nucleotides/metabolism
;
Aminophylline/*pharmacology/therapeutic use
;
Animals
;
Anoxia/physiopathology
;
Apnea/drug therapy
;
Brain/drug effects/*metabolism
;
Cheyne-Stokes Respiration/drug therapy
;
Cyclic AMP/metabolism
;
Energy Metabolism/*drug effects
;
Glucose/metabolism
;
Glucosephosphates/metabolism
;
Humans
;
Infant, Newborn
;
Infant, Newborn, Diseases/drug therapy
;
Mice
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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