Publication Date:
1998-12-16
Description:
alpha-Dystroglycan (alpha-DG) is a component of the dystroglycan complex, which is involved in early development and morphogenesis and in the pathogenesis of muscular dystrophies. Here, alpha-DG was shown to serve as a Schwann cell receptor for Mycobacterium leprae, the causative organism of leprosy. Mycobacterium leprae specifically bound to alpha-DG only in the presence of the G domain of the alpha2 chain of laminin-2. Native alpha-DG competitively inhibited the laminin-2-mediated M. leprae binding to primary Schwann cells. Thus, M. leprae may use linkage between the extracellular matrix and cytoskeleton through laminin-2 and alpha-DG for its interaction with Schwann cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rambukkana, A -- Yamada, H -- Zanazzi, G -- Mathus, T -- Salzer, J L -- Yurchenco, P D -- Campbell, K P -- Fischetti, V A -- New York, N.Y. -- Science. 1998 Dec 11;282(5396):2076-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Bacterial Pathogenesis and Immunology, Rockefeller University, New York, NY 10021, USA. rambuka@rockvax.rockefeller.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9851927" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
*Bacterial Adhesion
;
Binding Sites
;
Calcium/physiology
;
Cell Line, Transformed
;
Cells, Cultured
;
Cytoskeletal Proteins/*metabolism/pharmacology
;
Dystroglycans
;
Edetic Acid/pharmacology
;
Glycosylation
;
Humans
;
Laminin/chemistry/*metabolism
;
Membrane Glycoproteins/*metabolism/pharmacology
;
Mycobacterium leprae/*metabolism
;
Peripheral Nerves/chemistry
;
Rats
;
Receptors, Laminin/metabolism
;
Recombinant Fusion Proteins/metabolism
;
Recombinant Proteins/chemistry/metabolism
;
Schwann Cells/metabolism/*microbiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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