Publication Date:
1989-08-25
Description:
Cocaine abuse has reached epidemic proportions in the United States, and the search for an effective pharmacotherapy continues. Because primates self-administer most of the drugs abused by humans, they can be used to predict the abuse liability of new drugs and for preclinical evaluation of new pharmacotherapies for drug abuse treatment. Daily administration of buprenorphine (an opioid mixed agonist-antagonist) significantly suppressed cocaine self-administration by rhesus monkeys for 30 consecutive days. The effects of buprenorphine were dose-dependent. The suppression of cocaine self-administration by buprenorphine did not reflect a generalized suppression of behavior. These data suggest that buprenorphine would be a useful pharmacotherapy for treatment of cocaine abuse. Because buprenorphine is a safe and effective pharmacotherapy for heroin dependence, buprenorphine treatment may also attenuate dual abuse of cocaine and heroin.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mello, N K -- Mendelson, J H -- Bree, M P -- Lukas, S E -- DA-00101/DA/NIDA NIH HHS/ -- DA-02519/DA/NIDA NIH HHS/ -- DA-04059/DA/NIDA NIH HHS/ -- New York, N.Y. -- Science. 1989 Aug 25;245(4920):859-62.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Alcohol and Drug Abuse Research Center, Harvard Medical School, McLean Hospital, Belmont, MA 02178.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2772637" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Buprenorphine/*pharmacology/therapeutic use
;
Cocaine/*administration & dosage
;
Dose-Response Relationship, Drug
;
Female
;
Macaca mulatta
;
Male
;
Self Administration
;
Substance-Related Disorders/*drug therapy
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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