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  • Animals  (1)
  • Cytarabine/pharmacology  (1)
  • Polymer and Materials Science  (1)
  • Regeneration/*drug effects  (1)
  • 1
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    Retinoic acid stimulates regeneration of mammalian auditory hair cells (1993)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1993-04-30
    Description: Sensorineural hearing loss resulting from the loss of auditory hair cells is thought to be irreversible in mammals. This study provides evidence that retinoic acid can stimulate the regeneration in vitro of mammalian auditory hair cells in ototoxic-poisoned organ of Corti explants in the rat. In contrast, treatment with retinoic acid does not stimulate the formation of extra hair cells in control cultures of Corti's organ. Retinoic acid-stimulated hair cell regeneration can be blocked by cytosine arabinoside, which suggests that a period of mitosis is required for the regeneration of auditory hair cells in this system. These results provide hope for a recovery of hearing function in mammals after auditory hair cell damage.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lefebvre, P P -- Malgrange, B -- Staecker, H -- Moonen, G -- Van de Water, T R -- DC00088/DC/NIDCD NIH HHS/ -- NS07098/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1993 Apr 30;260(5108):692-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Human Physiology and Pathophysiology, University of Liege, Belgium.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8480180" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cytarabine/pharmacology ; Hair Cells, Auditory/*drug effects/physiology/ultrastructure ; Microscopy, Electron ; Neomycin/toxicity ; Organ Culture Techniques ; Organ of Corti/*drug effects/physiology/ultrastructure ; Rats ; Regeneration/*drug effects ; Tretinoin/*pharmacology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
    Electronic Resource
    Electronic Resource
    Preparation of a macroporous biodegradable polylactide implant for neuronal transplantation (1995)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 29 (1995), S. 1349-1362 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: This article reports the production of a surgical implant meeting several specific requirements such as biocompatibility, biodegradability, macroporosity, and flexibility. Porosity was controlled by an original method consisting of the aggregation of calibrated poly-D,L-lactide microparticles. The size of the interstices between the aggregated microspheres was in a direct relationship to the microsphere diameter. A first approach was based on coating the microspheres with poly(vinyl alcohol) followed by chemically crosslinking the coating layers that were in mutual contact. This method was disregarded because of the acute cytotoxicity of glutaraldehyde used as the crosslinking agent, the absence of macroporosity, and the complete lack of flexibility. A physical technique of aggregation was then tested, which relied on the plasticization of poly-D,L-lactide microspheres with triethylcitrate to the point where microspheres strongly adhered to each other when they were in contact. This method has proved to be straightforward and definitely superior to the chemical approach, particularly with respect to cytotoxicity, control of macroporosity, and flexibility. A polymer support was thus successfully produced which was biodegradable, macroporous (interconnected pores of 10-100 μm in diameter), and flexible. This potential medical device is presently being used for neuronal transplantation in the central nervous system. © 1995 John Wiley & Sons, Inc.
    Additional Material: 18 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jbm.820291106
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