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  • 1
    Publication Date: 2021-05-19
    Description: Se evaluó el uso de desechos de pescado frescos y ensilados (por acidificación y fermentación láctica), como única fuente de proteína animal en dietas semihúmedas para híbridos de Clarias gariepinus x Clarias macrocephalus (4,53 + 0,05 g de peso inicial promedio). Estas dietas se compararon con un alimento balanceado comercial (20 % de harina de desechos de pescado) durante 60 días. Los resultados mostraron que los mejores indicadores de crecimiento y utilización de la proteína se obtuvieron con los desechos frescos, los que difirieron significativamente (p 〈 0,05) de los ensilados y la harina de pescado; sin embargo, la conversión alimentaría (base seca) y supervivencia (〉 85 %) fue similar entre las dietas. Los ensilados y la harina de pescado no tuvieron diferencias significativas (p 〉 0,05) en los indicadores evaluados, por lo que constituye una alternativa para la producción de alimentos acuícolas para países en vía de desarrollo.
    Description: Fish offal waste and silage (by acidification and lactic fermentation), as a unique source of animal protein in half moist diets for Clarias gariepinus x Clarias macrocephalus hybrids (4,53 + 0,05 g initial middle weight) was assessed. These diets were compared with a balanced commercial food (20 % fish offal meal) during 60 days. The results showed that the best growth indicators and protein utilization were obtained by fresh wastes, which were significantly differed (p 〈 0,05) from silage and fish meal. However, the food conversion (dry base) and survival rate (〉85 %) were similar between the diets. Silage and fish meal did not significantly differed (p 〉 0,05) in the evaluated indicators; Therefore, this represents an alternative for aquaculture food production in developing countries.
    Description: Published
    Description: clarias
    Keywords: Feeding ; Fish wastes ; Fish wastes ; Fish silage ; Feeding
    Repository Name: AquaDocs
    Type: Journal Contribution
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  • 2
    Publication Date: 2021-05-19
    Description: El bagre africano Clarias gariepinus es la principal especie dulceacuícola que se cultiva en Cuba, por su rusticidad en las condiciones económicas actuales del país. La alimentación de esta especie se lleva a cabo con una dieta comercial de tilapias a base de soya (Toledo et al., 2007) y desechos del procesamiento pesquero, dado que su cultivo es principalmente en estanques de tierra. No obstante, en algunas granjas del país se hizo necesaria la utilización de la estanquería de cemento, donde se empleó solo la dieta comercial y los resultados de forma general tendieron a disminuir el desempeño productivo de la especie (Oliva et al., 2007). Como vía de aumentar el nivel de proteína del alimento comercial de tilapias (producción nacional), la harina de soya (HS) se incluyó al 50 %. Numerosos trabajos demostraron que altos niveles de HS reducen el crecimiento y la eficiencia alimentaria en diferentes especies de peces (Zhoug et al., 2005; Kasper et al., 2007). De igual forma, está bien documentada la disminución del valor nutritivo de las proteínas vegetales para organismos acuáticos, debido a la presencia de factores antinutrionales, deficiencias de aminoácidos esenciales y afectación de la palatabilidad (El-sayed et al., 2000; Goda et al., 2007a; Toledo et al., 2007).The objective of this work was to evaluate two foods effect in the productive performance for African catfish rearing in cement pond of 1 m3 during 50 days. 600 Clarias gariepinus fingerling (10,0 g of initial average weight) were used and distributed according to randomized design in two triplic treatment: a dry commercial tilapia diet as control (soybean meal as unique protein source) and other semi-humid experimental with 40 % of fishing waste silage and 60 % of control diet. The outcomes showed that there were statistical differences in the growth, the alimentary conversion, protein efficiency and survival in favour of the experimental diet. These results demonstrated that the inclusion of animal protein in diet for good productive indicators of the species rearing in cement ponds was necessary.
    Description: Published
    Description: Clarias, commercial tilapia diet
    Keywords: Fish silage ; Fish farms
    Repository Name: AquaDocs
    Type: Journal Contribution , Refereed , Article
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  • 3
    Publication Date: 2011-06-25
    Description: Author(s): R. Schmidt, C. Lazo, U. Kaiser, A. Schwarz, S. Heinze, and R. Wiesendanger We demonstrate that magnetic exchange force spectroscopy allows for a quantitative determination of the distance-dependent magnetic exchange interaction across a vacuum gap. Experiments were performed on the antiferromagnetic Fe monolayer on W(001) with magnetically sensitive tips and compared to fi... [Phys. Rev. Lett. 106, 257202] Published Fri Jun 24, 2011
    Keywords: Condensed Matter: Electronic Properties, etc.
    Print ISSN: 0031-9007
    Electronic ISSN: 1079-7114
    Topics: Physics
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  • 4
    Publication Date: 2012-02-02
    Description: Author(s): Hongbin Zhang, Cesar Lazo, Stefan Blügel, Stefan Heinze, and Yuriy Mokrousov Based on first-principles calculations, we predict that 5 d transition metals on graphene present a unique class of hybrid systems exhibiting topological transport effects that can be manipulated effectively by external electric fields. The origin of this phenomenon lies in the exceptional magnetic p... [Phys. Rev. Lett. 108, 056802] Published Wed Feb 01, 2012
    Keywords: Condensed Matter: Electronic Properties, etc.
    Print ISSN: 0031-9007
    Electronic ISSN: 1079-7114
    Topics: Physics
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  • 5
    Publication Date: 2010-05-21
    Description: Malaria caused by Plasmodium falciparum is a disease that is responsible for 880,000 deaths per year worldwide. Vaccine development has proved difficult and resistance has emerged for most antimalarial drugs. To discover new antimalarial chemotypes, we have used a phenotypic forward chemical genetic approach to assay 309,474 chemicals. Here we disclose structures and biological activity of the entire library-many of which showed potent in vitro activity against drug-resistant P. falciparum strains-and detailed profiling of 172 representative candidates. A reverse chemical genetic study identified 19 new inhibitors of 4 validated drug targets and 15 novel binders among 61 malarial proteins. Phylochemogenetic profiling in several organisms revealed similarities between Toxoplasma gondii and mammalian cell lines and dissimilarities between P. falciparum and related protozoans. One exemplar compound displayed efficacy in a murine model. Our findings provide the scientific community with new starting points for malaria drug discovery.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2874979/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2874979/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Guiguemde, W Armand -- Shelat, Anang A -- Bouck, David -- Duffy, Sandra -- Crowther, Gregory J -- Davis, Paul H -- Smithson, David C -- Connelly, Michele -- Clark, Julie -- Zhu, Fangyi -- Jimenez-Diaz, Maria B -- Martinez, Maria S -- Wilson, Emily B -- Tripathi, Abhai K -- Gut, Jiri -- Sharlow, Elizabeth R -- Bathurst, Ian -- El Mazouni, Farah -- Fowble, Joseph W -- Forquer, Isaac -- McGinley, Paula L -- Castro, Steve -- Angulo-Barturen, Inigo -- Ferrer, Santiago -- Rosenthal, Philip J -- Derisi, Joseph L -- Sullivan, David J -- Lazo, John S -- Roos, David S -- Riscoe, Michael K -- Phillips, Margaret A -- Rathod, Pradipsinh K -- Van Voorhis, Wesley C -- Avery, Vicky M -- Guy, R Kiplin -- AI045774/AI/NIAID NIH HHS/ -- AI053680/AI/NIAID NIH HHS/ -- AI067921/AI/NIAID NIH HHS/ -- AI075517/AI/NIAID NIH HHS/ -- AI075594/AI/NIAID NIH HHS/ -- AI080625/AI/NIAID NIH HHS/ -- AI082617/AI/NIAID NIH HHS/ -- AI28724/AI/NIAID NIH HHS/ -- AI35707/AI/NIAID NIH HHS/ -- AI53862/AI/NIAID NIH HHS/ -- AI772682/AI/NIAID NIH HHS/ -- CA78039/CA/NCI NIH HHS/ -- F32 AI077268/AI/NIAID NIH HHS/ -- F32 AI077268-03/AI/NIAID NIH HHS/ -- P01 AI035707/AI/NIAID NIH HHS/ -- P01 AI035707-140007/AI/NIAID NIH HHS/ -- P01 CA078039-10/CA/NCI NIH HHS/ -- P41 RR001614/RR/NCRR NIH HHS/ -- P41 RR001614-246970/RR/NCRR NIH HHS/ -- R01 AI045774/AI/NIAID NIH HHS/ -- R01 AI045774-09/AI/NIAID NIH HHS/ -- R37 AI028724/AI/NIAID NIH HHS/ -- R37 AI028724-17/AI/NIAID NIH HHS/ -- R56 AI082617/AI/NIAID NIH HHS/ -- R56 AI082617-01/AI/NIAID NIH HHS/ -- U01 AI053862/AI/NIAID NIH HHS/ -- U01 AI053862-05/AI/NIAID NIH HHS/ -- U01 AI075594-03/AI/NIAID NIH HHS/ -- UL1 TR000005/TR/NCATS NIH HHS/ -- Howard Hughes Medical Institute/ -- England -- Nature. 2010 May 20;465(7296):311-5. doi: 10.1038/nature09099.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Chemical Biology and Therapeutics, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20485428" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antimalarials/*analysis/isolation & purification/*pharmacology ; Cell Line ; *Drug Discovery ; Drug Evaluation, Preclinical ; Drug Resistance/drug effects ; Drug Therapy, Combination ; Erythrocytes/drug effects/parasitology ; Humans ; Malaria, Falciparum/drug therapy/parasitology ; Mice ; Phenotype ; Phylogeny ; Plasmodium falciparum/*drug effects/*genetics/metabolism ; Reproducibility of Results ; Small Molecule Libraries/chemistry/pharmacology
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 6
    Publication Date: 1988-09-30
    Description: Resistance to antineoplastic agents is the major obstacle to curative therapy of cancer. Tumor cell lines with acquired resistance to the antineoplastic agent cis-diamminedichloroplatinum(II) overexpressed metallothionein and demonstrated cross-resistance to alkylating agents such as chlorambucil and melphalan. Human carcinoma cells that maintained high levels of metallothionein because of chronic exposure to heavy metals were resistant to cis-diamminedichloroplatinum(II), melphalan, and chlorambucil. Furthermore, cells transfected with bovine papilloma virus expression vectors containing DNA encoding human metallothionein-IIA were resistant to cis-diamminedichloroplatinum(II), melphalan, and chlorambucil but not to 5-fluorouracil or vincristine. Thus, overexpression of metallothionein represents one mechanism of resistance to a subset of clinically important anticancer drugs.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kelley, S L -- Basu, A -- Teicher, B A -- Hacker, M P -- Hamer, D H -- Lazo, J S -- CA-01012/CA/NCI NIH HHS/ -- CA-38497/CA/NCI NIH HHS/ -- CA-43917/CA/NCI NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1988 Sep 30;241(4874):1813-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Pharmaceutical Research and Development Division, Bristol Myers Co., Wallingford, CT 06492.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3175622" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Antineoplastic Agents ; Blotting, Northern ; Cells, Cultured ; *Drug Resistance ; In Vitro Techniques ; Metallothionein/*physiology ; Mice
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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