Publication Date:
1985-03-22
Description:
Glutathione reductase from trypanosomes and leishmanias, unlike glutathione reductase from other organisms, requires an unusual low molecular weight cofactor for activity. The cofactor was purified from the insect trypanosomatid Crithidia fasciculata and identified as a novel glutathione-spermidine conjugate, N1,N8-bis(L-gamma-glutamyl-L-hemicystinyl-glycyl)spermidine, for which the trivial name trypanothione is proposed. This discovery may open a new chemotherapeutic approach to trypanosomiasis and leishmaniasis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fairlamb, A H -- Blackburn, P -- Ulrich, P -- Chait, B T -- Cerami, A -- 1 R01 A127429/PHS HHS/ -- 1 R01 AI19428/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1985 Mar 22;227(4693):1485-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3883489" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Chemical Phenomena
;
Chemistry
;
Coenzymes/analysis/*isolation & purification/metabolism
;
Crithidia/*enzymology
;
Glutathione/*analogs & derivatives/analysis/isolation & purification/metabolism
;
Glutathione Reductase/*metabolism
;
Leishmania/*enzymology
;
Oxidation-Reduction
;
Spermidine/*analogs & derivatives/analysis/isolation & purification/metabolism
;
Terminology as Topic
;
Trypanosoma/*enzymology
;
Trypanosoma brucei brucei/enzymology
;
Trypanosoma cruzi/enzymology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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