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  • 1
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Immunology. ; Biotechnology. ; Medicine Research. ; Biology Research. ; Immune system. ; Cellular signal transduction. ; Immunotherapy. ; Immunology. ; Biotechnology. ; Biomedical Research. ; Immune Cell Signalling. ; Immunotherapy. ; Applied Immunology.
    Description / Table of Contents: Chapter 1. Classification, Mode of Action and Uses of Various Immunomodulators -- Chapter 2. Potential role of herbs and spices on the immune system -- Chapter 3. Immune booster activity of Prebiotics -- Chapter 4. Antioxidants and Immunomodulation -- Chapter 5. Nanotechnology and Immunomodulators in Cancer -- Chapter 6. Advancements in the field of Oral, Intravenous and Inhaled Immunomodulators using Nanotechnology -- Chapter 7. Phytochemicals as the source of Natural Immunomodulator & their role in Cancer Chemoprevention -- Chapter 8. Immunomodulators and Autoimmune Liver Diseases -- Chapter 9. Immunomodulatory role for the treatment and management of tuberculosis -- Chapter 10. Immunomodulation in Autoimmune Disorders -- Chapter 11. Psychology, Epigenetics, Immunomodulation and Immune Dysfunction: Understanding the Connection -- Chapter 12. Herbal Immunomodulators and COVID-19 -- Chapter 13. Role of Cytokines as Immunomodulators -- Chapter 14. Immunomodulatory properties of proteins and peptides: Food derivates approach -- Chapter 15. Fatty Acids and Immunomodulation -- Chapter 16. Immunomodulatory Effects of Endocrine Disrupting Chemicals.-.
    Abstract: This book focuses on a broad range of immunomodulators, including both natural and synthetic ones. It highlights their role in human health. The book discusses nanotechnology-based immunomodulators with special emphasis on different types of formulation to boost the immune system. It highlights the role of immunomodulators against different microbes. This book describes important topics such as Classification and uses of various immunomodulators; Potential role of herbs and spices on immune system; Immune booster activity of prebiotics; Recent advances of nutraceutical and functional foods in Immune health; Antioxidants and immunomodulation; Nanotechnology and immunomodulators in cancer; Immunomodulatory role for the treatment and management of tuberculosis; Immunomodulation in autoimmune disorders; Herbal immunomodulators and COVID-19; Role of Cytokines as Immunomodulators and Immunomodulatory effects of endocrine disrupting chemicals. This book covers various aspects of product innovation, development, and launching of nutritional and pharmaceutical products with reference to immunomodulators. This book is meant for researchers and students in the field of immunology and pharmaceutical sciences.
    Type of Medium: Online Resource
    Pages: XVIII, 509 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811663796
    DDC: 571.96
    Language: English
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  • 2
    Keywords: Medicine Research. ; Biology Research. ; Cardiovascular system. ; Physiology. ; Cardiology. ; Clinical biochemistry. ; Biomedical Research. ; Cardiovascular Physiology. ; Cardiology. ; Medical Biochemistry.
    Description / Table of Contents: Past, present and future perspectives of renin angiotensin system -- Biochemical pathways of renin angiotensin system -- Structure-function relationships of angiotensin II receptors -- Signal transduction mechanism of angiotensin II -- Renin angiotensin system: Pathophysiology and clinical implications in cardiovascular disease COVID-19 infection -- Angiotensin II and the pathogenesis of hypertension -- Signaling transduction of angiotensin II in hypertension -- Role of angiotensin II type 1 receptors in vascular remodeling in hypertension -- Molecular and cellular mechanisms of renin-angiotensin system in hypertension -- Tissue renin-angiotensin system and risks in hypertension -- Oxidative stress and angiotensin II-induced hypertension -- Angiotensin II: inflammatory system disorder and hypertension -- Therapeutic approaches for angiotensin receptor blockers in hypertension -- Renin-angiotensin systems: A pivotal role in the development of atherosclerosis -- Angiotensin II induced intracellular signaling pathways in pathogenesis of atherosclerosis -- Cellular and molecular mechanisms of Ang II: Contribution to atherosclerotic plaque vulnerability -- Role of angiotensin II, nitric oxide and reactive oxygen species in atherosclerosis -- The renin-angiotensin system and inflammatory processes in atherosclerotic lesion formation -- Role of renin-angiotensin system in alterations in blood lipids and gene expression in atherogenesis -- Effects of angiotensin-converting enzyme and receptors in atherosclerosis -- Effects of angiotensin II on cardiac arrhythmia and signal transduction -- Angiotensin II induced oxidative stress contribute to ventricular arrhythmias -- Modulation of renin angiotensin system: Beneficial effect on ventricular arrhythmias -- ACE inhibitor and ventricular arrhythmia in ischemic heart disease -- The renin-angiotensin system modulators and cardiac arrhythmias -- Angiotensin receptor blockers in the treatment of arrhythmias -- Angiotensin II induced cardiac hypertrophy and heart failure -- Renin-angiotensin system: Role in cardiac remodeling and subcellular defects in heart failure -- Renin-angiotensin system: Molecular and cellular mechanisms in heart failure -- Role of angiotensin II receptor mRNA expression in heart failure -- Renin angiotensin system: Mitochondrial dysfunction in the progression of heart failure -- Angiotensin II type 1 receptor: Genetic polymorphisms and heart failure -- Angiotensin converting enzyme 2 and angiotensin metabolism in heart failure -- Cellular and molecular mechanisms of renin-angiotensin system blockade in heart failure: An update -- Angiotensin II receptor antagonists: Modulation of the extracellular matrix regulatory system in heart failure.
    Abstract: This book on “Renin-Angiotensin System in Cardiovascular Disease” includes 25 chapters, which are organized in three sections, namely (i) modulatory aspects, (ii) pathophysiological aspects, and (iii) pharmacotherapeutic aspects. It includes an updated as well as comprehensive knowledge about molecular and cellular aspects for the role of the renin-angiotensin system (RAS) in the pathophysiology and therapy of cardiovascular diseases such as hypertension, atherosclerosis, ischemic heart disease, and heart failure. This book emphasizes the molecular and cellular mechanisms, signaling transduction pathways involved in the development of different cardiovascular diseases due to the prolonged activation of RAS. Furthermore, biochemical mechanisms are outlined for the inhibition of this system by the blockade of angiotensin converting enzyme as well as angiotensin II type 1 receptors in patients suffering from cardiovascular abnormalities. Since cardiovascular disease is the number one cause of death worldwide, leading to approximately 17.9 million deaths each year, there is a keen interest in understanding the pathogenesis and improving its therapy. In this regard, we can attest that this book provides ample information about essential components of RAS and their role in the development of cardiovascular disease. From the selection of recognized global experts in their area of investigation, this book can be seen to cover diverse cardiovascular aspects and molecular and cellular mechanisms of angiotensin II action for the development of different cardiovascular abnormalities. It is our contention that this book will be most suitable for promoting knowledge in the field of RAS biology and will be of great interest to health professionals involved in both experimental and clinical cardiology as well as academic investigators and cardiovascular scientists, graduate students, and fellows worldwide.
    Type of Medium: Online Resource
    Pages: XVIII, 452 p. 71 illus., 54 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031149528
    Series Statement: Advances in Biochemistry in Health and Disease, 24
    DDC: 610.72
    Language: English
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  • 3
    Keywords: Medicine Research. ; Biology Research. ; Clinical biochemistry. ; Biochemistry. ; Psychology. ; Dentistry. ; Endocrinology. ; Biomedical Research. ; Medical Biochemistry. ; Biochemistry. ; Behavioral Sciences and Psychology. ; Dentistry. ; Endocrinology.
    Description / Table of Contents: Part 1: What is Salivary Bioscience, Why is it Important, and How Do We Study It? -- Chapter 1: Foundations of Interdisciplinary Salivary Bioscience: An Introduction (Granger et al.) -- Chapter 2: Salivary Gland Anatomy and Physiology (Hernández et al.) -- Chapter 3: Saliva Collection, Handing, Transport, and Storage: Special Considerations and Best Practices for Interdisciplinary Salivary Bioscience(Padilla et al.) -- Chapter 4: Analytical Strategies and Tactics in Salivary Bioscience (Riis et al.) -- Part 2: Physiology and Development Research and Applications (Part 2 Editor: Dr. Jenna Riis) -- Chapter 5: Salivary Bioscience, Human Stress, and the Hypothalamic Pituitary Adrenal Axis (Clow et al.) -- Chapter 6: The Use of Saliva for Genetics and Epigenetics Research (Nemoda et al.) -- Chapter 7: Saliva as a Window Into the Human Oral Microbiome and Metabolome(Whiteson et al.) -- Chapter 8: Salivaomics, saliva Exo-somics, and Saliva Liquid Biopsy (Wong et al.) -- Chapter 9: Salivary Bioscience, Immunity, and Inflammation (Riis et al.) -- Chapter 10:Salivary Bioscience and Human Development (Hibel et al.) -- Part 3: Biomedical Research and Related Applications (Part 3 Editor: Dr. Elizabeth Thomas) -- Chapter 11: Biomedical Research and Related Applications:Current Assay Methods and Quality Requirements in Oral Fluid Diagnostics Applications (Granger S. et al.) -- Chapter 12: Salivary Biomarkers and Neurodegenerative Conditions (Thomas et al.) -- Chapter 13: The Use of Antibodies in Saliva to Measure PathogenExposure and Infection(Heaney et al.) -- Chapter 14: Salivary Bioscience and Pain (Payne et al.) -- Chapter 15: Salivary Bioscience and Environmental Exposure Assessment (Panuwet et al.) -- Chapter 16: Saliva and Drugs of Abuse (Navazesh et al.) -- Chapter 17: Therapeutic Drug Monitoring in Saliva (Thomas) -- Chapter 18: Salivary Bioscience and Periodontal Medicine (Freire et al.) -- Chapter 19: Salivary Bioscience and Cancer (Navazesh et al.) -- Part 4: Psychosocial Research and Applications(Part 4 Editor: Dr. Kate Ryan Kuhlman) -- Chapter 20: Salivary Bioscience in Clinical Psychologyand Psychiatry(Kuhlman) -- Chapter 21: Salivary Bioscience Research in Health Psychology and Behavioral Medicine (Hoyt et al.) -- chapter 22: The Neuroscience of Human Social Behavior: A Review of How Testosterone and Cortisol Underpin Competition and Affiliation Dynamics (Kornienko et al.) -- chapter 23: Salivary Studies of the Social Neuroscience of Human-animal Interaction (Pendry et al.) -- Part 5: Population Health Research and Applications(Part 5 Editor: Dr. Marcus Taylor) -- Chapter 24: Salivary Bioscience and Military, Space, and OperationalResearch(Roma et al.) -- Chapter 25: Salivary Bioscience Research Related to Prenatal Adversity (Eiden et al.) -- Chapter 26: Salivary Bioscience and Pediatrics (Johnson et al.) -- Chapter 27: Use of saliva to better understand the experience of adulthood and aging(Almeida et al.) -- Chapter 28: Salivary Bioscience and Research on Animal Welfare and Conservation Science(Staley et al.) -- Part 6: The Way Forward: Future Directions for the Science and Practice of Salivary Bioscience -- Chapter 29:Applications of Salivary Bioscience to Precision Medicine (Kuhlman) -- Chapter 30:Public Health and IndustryApplications of Salivary Bioscience (Riis et al.) -- Chapter 31: Envisioning the Future of Interdisciplinary Salivary Bioscience (Granger et al.).
    Abstract: This book provides the first comprehensive overview of the emerging field of interdisciplinary salivary bioscience. It serves as a foundational reference guide to the collection, analysis, and interpretation of salivary data, as well as its myriad applications in medicine, surveillance and public health. The ease and non-invasive nature of saliva collection makes it highly useful in diverse fields such as pediatrics, dentistry, neuroscience, psychology, animal welfare and precision medicine. This book introduces students and scientists alike to the vast potential of salivary bioscience in both research and practice.
    Type of Medium: Online Resource
    Pages: XIV, 751 p. 56 illus., 40 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030357849
    DDC: 610.72
    Language: English
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  • 4
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Medicine Research. ; Biology Research. ; Pharmacology. ; Biomedical Research. ; Pharmacology.
    Description / Table of Contents: Part 1 General and Principles of Toxicology -- A Historical Glimpse and Stalwarts -- General Toxicology -- Principles of Toxicology -- Mechanism of Toxicity -- Part 2 Disposition and Kinetics -- Disposition of Toxicants -- Toxicokinetic of Xenobiotics -- Part3 Organ Toxicity -- Target Organ Toxicity -- Part4 Non-Organ-Directed Toxicity -- chemical carcinogenesis -- Genetic Toxicology -- Developmental Toxicology -- Part5 Toxic Agents -- Pesticides -- Metals and Micronutrients -- Solvents. Gasses and Vapors -- Toxicology of Nanomaterial Particles -- Toxic Effects of Calories -- Part6 Plants, Biotoxins and Food Poisonings -- Plant Toxicity -- Biotoxins and Venomous Organisms -- Poisonous Foods and Food Poisonings -- Part7 Radioactive Materials -- Radiation and Radioactive Materials -- Part8 Applications of Toxicology -- Food Toxicology -- Ecotoxicology -- Environmental Toxicology -- Analytical and Clinical Toxicology -- Occupational Toxicology. .
    Abstract: The book provides easy-to-understand diverse specialized topics in toxicology using self- study questions and answers. The answers are in the form of text along with custom made diagrams and explanations that help the student audience to understand and grasp the matter easily. Problem Solving Questions in Toxicology is written specifically as a study guide for the toxicology board and other examinations. .
    Type of Medium: Online Resource
    Pages: XV, 346 p. 46 illus., 27 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030504090
    DDC: 610.72
    Language: English
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  • 5
    Keywords: Medicine Research. ; Biology Research. ; Food science. ; Agriculture. ; Biomedical Research. ; Food Science. ; Agriculture.
    Description / Table of Contents: Chapter 1. Millets-an Overview -- Chapter 2. Millet Cultivation an Overview -- Chapter 3. Millet Storage and Pest Management -- Chapter 4. Major Millets Processing -- Chapter 5. Minor millet processing and its impacts on composition -- Chapter 6. Chemistry of Millets: Major and Minor Constituents -- Chapter 7. Nutritional properties of millets: neglected cereals with potentials to combat malnutrition -- Chapter 8. Post-harvest Treatments and Storage of millets -- Chapter 9. Millet Milling Technologies -- Chapter 10. Effect of Processing on Functional Characteristics, Physiochemical Properties, and Nutritional Accessibility of Millets -- Chapter 11. Emerging Technologies in Millet Processing -- Chapter 12. Millet Food Products -- Chapter 13. Byproducts from Millet Processing Industry -- Chapter 14. Quality Standards for Millets -- Chapter 15. Millet Industry Scenario -- Chapter 16. Toxins in Millets.-.
    Abstract: The book offers an updated perspective on the unique characteristics of millets. Millets are consumed for their health/nutritional benefits, and in the preparation of specialty foods for target groups – from pediatrics to geriatrics. Recent trends suggest the importance of millet in the human diet due to their nutritional importance, ability to grow in high temperatures and drought conditions, and their resistance to pests and diseases. This book highlights different types of millet and discusses their properties as well as nutritional and anti-nutritional values. In addition, the book also provides information on the physiochemical properties, future prospects, current methodologies, and agricultural practices. The last few parts cover the emerging technologies in millet processing, by-products utilization, quality standards, and the current millet industry scenario. The book provides a comprehensive overview of the status of millet processing, quality, and nutraceutical product manufacture. The book is a resourceful read for students and researchers in food sciences, as well as industry experts.
    Type of Medium: Online Resource
    Pages: VII, 386 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811672248
    DDC: 610.72
    Language: English
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  • 6
    Keywords: Medicine Research. ; Biology Research. ; Medical microbiology. ; Internal medicine. ; Biomedical Research. ; Medical Microbiology. ; Internal Medicine.
    Description / Table of Contents: 1. Inflammatory components of the thyroid cancer microenvironment - an avenue for identification of novel biomarkers -- 2. Disruption of Cell-Cell Communication in Anaplastic Thyroid Cancer as an Immunotherapeutic Opportunity -- 3. Exosomes in the Healthy and Malignant Bone Marrow Microenvironment -- 4. Structural Biology of the Tumor Microenvironment -- 5. Metabolic interactions between tumor and stromal cells in the Tumor Microenvironment -- 6. Interacting Genetic Lesions of Melanoma in the Tumor Microenvironment: Defining a Viable Therapy -- 7. Non-coding RNAs in Papillary Thyroid Cancer: Interaction with cancer associated fibroblasts (CAFs) in the Tumor Microenvironment (TME) and regulators of differentiation and Lymph Node Metastasis.
    Abstract: Over the past decade, the tumor microenvironment has become one of the most important research areas in cancer biology, as cells within the tumor microenvironment, despite being outnumbered by healthy cells, are able to evade surveillance and immune-mediated destruction. While researchers have learned a great deal about the cellular and structural makeup of the tumor microenvironment, there has been a growing understanding of the metabolic interplay between the tumor microenvironment's various cellular constituents and how each of them contributes to overall tumor growth and metastases. This new volume will guide researchers, students, oncologists and academics through a rapidly developing and changing field with a thorough understanding of tumor microenvironment biology from a cellular, structural, metabolic, and immunological perspective.
    Type of Medium: Online Resource
    Pages: XIII, 164 p. 19 illus., 15 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030832827
    Series Statement: Advances in Experimental Medicine and Biology, 1350
    DDC: 610.72
    Language: English
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  • 7
    Keywords: Medicine Research. ; Biology Research. ; Drug delivery systems. ; Genetics Research. ; Imaging systems in biology. ; Biology Technique. ; Biomedical Research. ; Drug Delivery. ; Genetics Research. ; Biological Imaging. ; Biological Techniques.
    Description / Table of Contents: Chapter 1. Editorial: Biosystems -- 2. Potential of Biotechnology in cancer management -- 3. Biosimilars: Promising and Rapidly Emerging Biotherapeutics -- 4. Applications of Nanomaterials in Medicine: Current status and future scope -- 5. Biomedical Applications of Nanofluids in Drug Delivery.
    Abstract: The book gives an insight into the theoretical background, conceptual understanding, latest developments, and applications in the field of pharmaceuticals in general and drug design, discovery, biosystems, and biomedical and drug delivery technologies in particular . Knowledge is drawn from various disciplines such as Chemistry, Biology, Material Science and Engineering, Statistics, Biomedicine, and Genetics . A host of applications like bio-imaging, novel biological agents, testing, characterization and validation of drugs, computer-based models in drug design, and application of statistical tools in data analysis, design, and development of drug delivery systems, and ecosystems are dealt with in detail. The said book undoubtedly confirms the requirements of the postgraduate students, research scholars, academicians, scientists, and researchers from the academia, pharmaceutical, biotechnology, and chemical engineering domain. The book covers a conceptual understanding of the exploration of drugs in tandem with intended uses, sound ecosystem development, and carriers for drug and supplement delivery.
    Type of Medium: Online Resource
    Pages: XX, 289 p. 58 illus., 48 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819952816
    DDC: 610.72
    Language: English
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  • 8
    Keywords: Medicine Research. ; Biology Research. ; Biomedical Research.
    Description / Table of Contents: Part I. Oxygen Metabolism and Health Monitoring -- Chronic Ketosis Modulates HIF1α Mediated Inflammatory Response in Rat Brain -- Event Related NIRS and EEG Analysis for Mental Stress Monitoring -- Simulation Study of Breast Cancer Lipid Changes Affecting Membrane Oxygen Permeability -- Updated Evaluation of Cholesterol’s Influence of Oxygen Permeability -- Systems biology model of cerebral oxygen delivery and metabolism during therapeutic hypothermia: application to the piglet model -- Effect of Adrenaline on Cerebral Blood Oxygenation Measured by NIRS in a Rat Asphyxia Cardiac Arrest Model -- Two consecutive invasive surgeries utilizing Zymogen Protein C (ZPC) that enhanced patient safety and reduced costs -- Scanning Tissue-Oxygen Needle-Probe -- Transcranial photobiomodulation of clearance of beta-amyloid from the mouse brain: the effects on meningeal lymphatic drainage and blood oxygen saturation of the brain -- Near-Infrared Spectroscopy Might Help Prevent Onset of Cerebral Hyperperfusion Syndrome -- Part II. Oxygen Measurement and Modeling -- Online assessment of hemodynamics in suctioned volume of biological tissue by the embedded Near-infrared Spectroscopy sensor -- Skeletal Muscle Deoxygenation and its Relationship to Aerobic Capacity During Early and Late Stages of Aging -- Near-Infrared Spectroscopy (NIRS) of Muscle HbO2 and MBO2 Desaturation During Exercise -- Relationship between Corticosteroid Dose and Muscle Oxygen Consumption in Recipients of Hematopoietic Stem-Cell Transplantation -- Relationship between the Borg Scale Rating of Perceived Exertion and Leg Muscle Deoxygenation during Incremental Exercise in Healthy Adults -- Effects of Exercise Training on Cardiac and Skeletal Muscle Functions in Patients in Chronic Heart Failure -- Reduced Scattering Coefficient During Incremental Exercise is Constant without being Affected by Changes in Muscle Oxygenation or Hemodynamics -- Changes in the laterality of oxygenation in the prefrontal cortex and premotor area during a 20-min moderate-intensity cycling exercise -- Relationship Between Decrease of Oxygenation During Incremental Exercise, Partial Pressure End-Tidal Carbon Dioxide: Near-Infrared Spectroscopy Vector Analysis -- Cerebral Oxygenation Dynamics during Incremental Exercise: Comparison of Arm Cranking and Leg Cycling -- Localization of Deep of Deep Ischemia and Hemorrhage in Preterm Infants’ Head with Near Infrared Optical Tomography: A Numerical Case Study -- Discerning Membrane Steady-State Oxygen Flux by Monte Carlo Markov Chain Modeling -- Part III. Tumor Oxygenation and Modeling -- Role of MicroRNA Expression for Proliferation and Apoptosis of Tumor Cells: Impact of Hypoxia-Related Acidosis -- Functional Impact of Acidosis-regulated MicroRNAs on the Migration and Adhesion of Tumor Cells -- Impact of Acidosis-Regulated MicroRNAs on the Expression of Their Target Genes in Experimental Tumors In Vivo -- An Observation on Enhanced Extracellular Acidification and Lactate Production Induced by Inhibition of Lactate Dehydrogenase A -- Keynote Lecture - The Warburg Effect: Historical Dogma versus Current Rationale -- The Acidic Tumor Microenvironment Affects Epithelial-Mesenchymal Transition Markers as well as Adhesion of NCI-H358 Lung Cancer Cells -- Assessment of the probability of tumor control for prescribed doses based on imaging of oxygen partial pressure -- On the feasibility of Pulse Wave Velocity Imaging for remote assessment of physiological functions -- Mechanisms of sound-induced opening of the blood-brain barrier -- Multimodal measurements of brain tissue metabolism and perfusion in a neonatal model of hypoxic-ischaemic injury -- Cerebral Spreading Depression Transient Disruption of Cross Frequency Coupling in the Rat Brain: Preliminary Observations -- Long-Term Blue Light Exposure Changes Frontal and Occipital Cerebral Hemodynamics: Not all Subjects React the Same -- Changes in Prefrontal Cortex Asymmetry Due to Standing Loading in Stroke Patients Measured by NIRS -- Parasympathetic Nervous Activity Associated with Discoordination between Physical Acceleration and Heart Rate Variability in Patients with Sleep Apnea -- The Changes in Brain Oxygenation during Transcranial Alternating Current Stimulation as Consequences of Traumatic Brain Injury: A Near-infrared Spectroscopy Study -- Error Evaluation for Automated Diameter Measurements of Cerebral Capillaries Captured with Two-Photon Laser Scanning Fluorescence Microscopy -- Potential Biomarker for Triple Negative Breast Cancer Invasiveness by Optical Redox Imaging -- Optical redox imaging differentiates triple-negative breast cancer subtypes -- Oxygen-sensing Paramagnetic Probes for Clinical Oximetry -- Evaluation of the Quality of Chest Compression with Oxy-hemoglobin Level by Near-infrared Spectroscopy in a Rat Asphyxia Cardiac Arrest Model -- Altered Behavioural Performance in the Neuron-specific HIF-1 and HIF-2 deficient mice following Chronic Hypoxic Exposure -- Effect of Adrenaline on Cerebral Blood Oxygenation Measured by NIRS in a Rat Asphyxia Cardiac Arrest Model -- Addition of Drag Reducing Polymers to Colloid Resuscitation Fluid Enhances Cerebral Microcirculation and Tissue Oxygenation after Traumatic Brain Injury Complicated by Hemorrhagic Shock -- Effects of 20-minute intensive exercise on subjects with different working memory bases -- Supine cycling exercise enhances cerebral oxygenation of motor-related areas in healthy male volunteers -- Keynote Lecture - What is the Meaning of an Oxygen Measurement? Analysis of methods purporting to measure oxygen in targeted tissues -- Part IV. Brain Oxygenation and Function -- Assessment of Cerebral Blood Oxygenation by Near-Infrared Spectroscopy before and after Resuscitation in A Rat Asphyxia Cardiac Arrest Model -- Effect of 3-Day and 21-Day Hypoxic Preconditioning on Recovery following Cerebral Ischemia in Rats -- Time Series Tracking of Cerebral Microvascular Adaptation to Hypoxia and Hyperoxia Imaged with Repeated in vivo Two-Photon Microscopy -- Environmental Enrichment Improved Cognitive Performance in Mice under Normoxia and Hypoxia -- Effect of Prolonged Pressure on Hemodynamics of Sacral Tissues Assessed by Diffuse Optical Imaging: A Pilot Study -- In-phantom Validation of Time-Domain Near-Infrared Optical Tomograph Pioneer for Imaging Brain Hypoxia and Hemorrhage -- Online Non-invasive Assessment of Human Brain Death by Near-infrared Spectroscopy with Protocol of O2 Inspiration -- Not removing the glossy white cover from adhesive INVOS neonatal sensors affects the oxygenation measurement -- Probe design optimization for time-domain NIROT ‘Pioneer’ system for imaging the oxygenation of the preterm brain -- Effect of blood flow on hemoglobin and myoglobin oxygenation in contracting muscle using near infrared spectroscopy -- Magnetoresistance Properties of Red Blood Cells in Plasma Combined with Several Magnetic Beads Passing Two Cu Electrodes -- Measurement of Tissue Oxygen as a Novel Approach to Optimizing Red Blood Cell Quality Assessment -- Prox-1 and Hif-1a Genes Expression of Primo Vessel in Rabbit’s Lymphatic Vessel -- On the Feasibility of Pulse Wave Velocity Imaging for Remote Assessment of Physiological Functions -- Index.
    Abstract: This book presents cutting-edge papers and perspectives on the transport of oxygen to tissues by scientists in a multitude of disciplines such as biochemistry, engineering, mathematics, medicine, physics, physiology, veterinary and complementary medicine. The book is composed of the following 6 parts: Brain Oxygenation and Function, Tumor Oxygenation and Metabolism, Muscle Oxygenation and Sports Medicine, Cell Metabolism and Tissue Oxygenation, Methodology of O2 Measurements, and Special Topics. The articles in this book have been presented at the 42nd annual meeting of the International Society on Oxygen Transport to Tissue (ISOTT 2019) held in Albuquerque, New Mexico, USA, from July 28 to July 31, 2019. Academics, clinical and industry researchers, engineers, as well as graduate students who are interested in oxygen transport to tissue will find this book a great reference and a useful learning resource. The chapters "Near-Infrared Spectroscopy Measured Cerebral Blood Flow from Spontaneous Oxygenation Changes in Neonatal Brain Injury", "Developing a Model to Simulate the Effect of Hypothermia on Cerebral Blood Flow and Metabolism" and "Broadband NIRS Cerebral Evaluation of the Hemodynamic and Oxidative State of Cytochrome-c-Oxidase Responses to +Gz Acceleration in Healthy Volunteers" are available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
    Type of Medium: Online Resource
    Pages: XVI, 412 p. 166 illus., 95 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030482381
    Series Statement: Advances in Experimental Medicine and Biology, 1269
    DDC: 610.72
    Language: English
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  • 9
    Keywords: Medicine Research. ; Biology Research. ; Human physiology. ; Cancer. ; Cancer Treatment. ; Virology. ; Therapeutics. ; Biomedical Research. ; Human Physiology. ; Cancer Biology. ; Cancer Therapy. ; Virology. ; Therapeutics.
    Description / Table of Contents: 1. Implications of renin-angiotensin system in health and disease -- 2. Renin angiotensin system and aging -- 3. The interplay of the renin-angiotensin system and solid organ transplantation -- 4. Correlation between renin angiotensin system and infectious disease -- 5. Emerging contributions of endocrine pathophysiology in virus-related infectious disease -- 6. Understanding the renin-angiotensin system in coronavirus disease 2019 -- 7. Metabolomics approach in differentiating RAS responses in ARDS (Acute respiratory distress syndrome) and SAR-CoV-2 -- 8. A Comprehensive review of the impact of the renin angiotensin system in the liver, lung, infectious diseases and cancers -- 9. Application of biosensors for monitoring changes in renin angiotensin system (RAS) in cancers and lung diseases -- 10. Bioinformatics study on renin angiotensin in lung, and liver cancer using plant-based extracts -- 11. Role of renin-angiotensin system in the pathogenesis and progression of non-alcoholic fatty liver -- 12. The classical and nonclassical renin-angiotensin-aldosterone system in liver cirrhosis -- 13. Renin-angiotensin-aldosterone system role in organ fibrosis -- 14. Role of renin angiotensin-aldosterone system in kidney homeostasis -- 15. Renin-angiotensin system in chronic kidney disease: Implications in stroke outcome -- 16. The renin-angiotensin system and cancer -- 17. Renin-angiotensin system and cancer: From laboratory to clinics -- 18. Role of renin-angiotensin system in cancer cachexia -- 19. Renin angiotensin system activity in different cancers: Mechanistic insight and preclinical studies -- 20. The new dimension of the renin-angiotensin system in the hallmarks of cancer -- 21. Renin-angiotensin system in hematological malignancies -- 22. Renin angiotensin system (RAS): The common thread between cancer and heart failure -- 23. Renin-angiotensin system: a potential therapeutic target for colorectal cancer -- 24. Anticancer role of natural phenolic acids by targeting angiotensin-converting enzyme (ACE) -- 25. Angiotensin-(1-7): A Prospective Cancer Therapeutic.
    Abstract: This book of the series on “Advances in Biochemistry in Health and Disease” includes state-of-the-art information on the status of renin-angiotensin system (RAS) in the form of 24 chapters. This book has been organized into three sections: (i) General Implications of RAS in human health and Infectious Diseases, (ii) Lung, Liver and Kidney Diseases, and (iii) Development of Cancer. Each chapter has discussed comprehensive knowledge regarding the molecular and cellular aspects of the role of RAS in the pathophysiology and pharmacotherapy of different disease processes. Biochemical mechanisms associated with angiotensin II type 1 and type II receptors, and angiotensin (1-7) MAS receptors for the occurrence of both harmful and beneficial effects of prolonged activation of RAS in different diseases have been outlined. It is noteworthy to point out that different chapter in this book were prepared by recognized global expertise in the area of inflammation, oxidative stress and signal transduction pathways to highlight the role of RAS in different diseases. It is our sincere hope that this book will be of great interest to both biomedical investigators and health professionals as well as graduate students and postdoctoral fellows all over the world.
    Type of Medium: Online Resource
    Pages: XX, 498 p. 70 illus., 63 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031236211
    Series Statement: Advances in Biochemistry in Health and Disease, 25
    DDC: 610.72
    Language: English
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  • 10
    Keywords: Medicine Research. ; Biology Research. ; Biophysics. ; Biomechanics. ; Immunology. ; Bones. ; Biomedical engineering. ; Biomedical Research. ; Biophysics. ; Biomechanics. ; Osteoimmunology. ; Biomedical Engineering and Bioengineering.
    Description / Table of Contents: Preface (Brianne K. Connizzo, Lin Han, Robert L. Sah) -- Scientific Impact -- Chapter 1. Aggrecan and Hyaluronan: The infamous Cartilage Polyelectrolytes- Then and Now (Anna Plaas, Meghan Moran, John Sandy, Vincent Hascall) -- Chapter 2. Understanding the Influence of Local Physical Stimuli on Chondrocyte Behavior (Byumsu Ki, Lawrence J. Bonassar) -- Chapter 3. Multiscale In Silico Modeling of Cartilage Injuries (Rami K. Korhonen, Atte S.A. Eskelinen, Gustavo A. Orozco, Amir Esrafilian, Cristina Florea, and Petri Tanska) -- Chapter 4. In Vitro Models and Proteomics in Osteoarthritis Research (Martin Rydén, Patrik Önnerfjord) -- Chapter 5. Nanomechanics of Aggrecan: A New Perspective on Cartilage Biomechanics, Disease and Regeneration (Chao Wang, Elizabeth R. Kahle, Lin Han) -- Chapter 6. Computational Modelling for Managing Pathways to Cartilage Failure (Saeed Miramini, David W. Smith, Bruce S. Gardiner, Lihai Zhang) -- Chapter 7. Gene Delivery to Chondrocytes (Christopher V. Nagelli, Christopher H. Evans, Rodolfo E. De la Vega) -- Chapter 8. Mechanical Articular Cartilage Injury Models and Their Relevance in Advancing Therapeutic Strategies (Bodo Kurz, Melanie L Hart, Bernd Rolauffs) -- Chapter 9. Hip Osteoarthritis: Bench to Bedside Perspective (Young-Jo Kim) -- Chapter 10. Harnessing Growth Factor Interactions to Optimize Articular Cartilage Repair (Stephen B. Trippel) -- Personal Tributes -- Index.
    Abstract: This is an open access book. In honor of his 75th birthday, we reflect on the impact of the pioneering work of Alan Grodzinsky and his laboratory. This volume includes in-depth discussions of tissue electromechanics, mechanobiology and biomechanics, and matrix biology in addition to the latest advancements in understanding the pathogenesis, progression and treatment of osteoarthritis. Unique to this volume, we overview decades of groundbreaking research that set the stage for the latest efforts in the field, highlighting the legacy of one researcher and their trainees.
    Type of Medium: Online Resource
    Pages: XIV, 173 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031255885
    Series Statement: Advances in Experimental Medicine and Biology, 1402
    DDC: 610.72
    Language: English
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