Publication Date:
1997-07-11
Description:
Structural changes in the extracellular matrix are necessary for cell migration during tissue remodeling and tumor invasion. Specific cleavage of laminin-5 (Ln-5) by matrix metalloprotease-2 (MMP2) was shown to induce migration of breast epithelial cells. MMP2 cleaved the Ln-5 gamma2 subunit at residue 587, exposing a putative cryptic promigratory site on Ln-5 that triggers cell motility. This altered form of Ln-5 is found in tumors and in tissues undergoing remodeling, but not in quiescent tissues. Cleavage of Ln-5 by MMP2 and the resulting activation of the Ln-5 cryptic site may provide new targets for modulation of tumor cell invasion and tissue remodeling.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Giannelli, G -- Falk-Marzillier, J -- Schiraldi, O -- Stetler-Stevenson, W G -- Quaranta, V -- CA47858/CA/NCI NIH HHS/ -- DE10063/DE/NIDCR NIH HHS/ -- New York, N.Y. -- Science. 1997 Jul 11;277(5323):225-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cell Biology, Scripps Research Institute, La Jolla, CA 92037, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9211848" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Breast/*cytology/metabolism
;
Cell Adhesion
;
Cell Adhesion Molecules/*metabolism
;
Cell Division
;
Cell Line
;
*Cell Movement
;
Cell Size
;
Collagenases/metabolism
;
Epithelial Cells
;
Epithelium/metabolism
;
Extracellular Matrix/*metabolism
;
Female
;
Fibrinolysin/metabolism
;
Gelatinases/antagonists & inhibitors/*metabolism
;
Humans
;
Matrix Metalloproteinase 2
;
Matrix Metalloproteinase 9
;
Metalloendopeptidases/antagonists & inhibitors/*metabolism
;
Mice
;
Phenylalanine/analogs & derivatives/pharmacology
;
Protease Inhibitors/pharmacology
;
Rats
;
Recombinant Fusion Proteins/metabolism
;
Skin Neoplasms/metabolism/pathology
;
Thiophenes/pharmacology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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