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  • Animals  (2)
  • CALYPSO; Calypso Corer; Counting; DEPTH, sediment/rock; Globigerina bulloides; Globigerina digitata; Globigerina falconensis; Globigerina rubescens; Globigerinella aequilateralis; Globigerinella calida; Globigerinita glutinata; Globigerinoides conglobatus; Globigerinoides ruber; Globigerinoides sacculifer; Globigerinoides tenellus; Globoquadrina conglomerata; Globorotalia crassaformis; Globorotalia inflata; Globorotalia menardii; Globorotalia scitula; Globorotalia truncatulinoides dextral; Globorotalia truncatulinoides sinistral; IMAGES; IMAGES III - IPHIS; International Marine Global Change Study; Marion Dufresne (1995); MD106; MD972151; MD97-2151; Neogloboquadrina dutertrei; Neogloboquadrina pachyderma sinistral; Orbulina universa; Pulleniatina obliquiloculata; South China Sea; Sphaeroidinella dehiscens  (1)
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  • 1
    Publication Date: 2008-10-22
    Description: Variable, diversity and joining (V(D)J) recombination and class-switch recombination use overlapping but distinct non-homologous end joining pathways to repair DNA double-strand-break intermediates. 53BP1 is a DNA-damage-response protein that is rapidly recruited to sites of chromosomal double-strand breaks, where it seems to function in a subset of ataxia telangiectasia mutated (ATM) kinase-, H2A histone family member X (H2AX, also known as H2AFX)- and mediator of DNA damage checkpoint 1 (MDC1)-dependent events. A 53BP1-dependent end-joining pathway has been described that is dispensable for V(D)J recombination but essential for class-switch recombination. Here we report a previously unrecognized defect in the joining phase of V(D)J recombination in 53BP1-deficient lymphocytes that is distinct from that found in classical non-homologous-end-joining-, H2ax-, Mdc1- and Atm-deficient mice. Absence of 53BP1 leads to impairment of distal V-DJ joining with extensive degradation of unrepaired coding ends and episomal signal joint reintegration at V(D)J junctions. This results in apoptosis, loss of T-cell receptor alpha locus integrity and lymphopenia. Further impairment of the apoptotic checkpoint causes propagation of lymphocytes that have antigen receptor breaks. These data suggest a more general role for 53BP1 in maintaining genomic stability during long-range joining of DNA breaks.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3596817/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3596817/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Difilippantonio, Simone -- Gapud, Eric -- Wong, Nancy -- Huang, Ching-Yu -- Mahowald, Grace -- Chen, Hua Tang -- Kruhlak, Michael J -- Callen, Elsa -- Livak, Ferenc -- Nussenzweig, Michel C -- Sleckman, Barry P -- Nussenzweig, Andre -- R01AI074953/AI/NIAID NIH HHS/ -- Z01 BC010283-10/Intramural NIH HHS/ -- Howard Hughes Medical Institute/ -- England -- Nature. 2008 Nov 27;456(7221):529-33. doi: 10.1038/nature07476. Epub 2008 Oct 19.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892-1360, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18931658" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Apoptosis ; Chromosomal Proteins, Non-Histone ; DNA/genetics/*metabolism ; DNA Breaks ; DNA-Binding Proteins ; Gene Rearrangement, T-Lymphocyte/*genetics ; Genes, T-Cell Receptor alpha/genetics ; Genomic Instability ; Intracellular Signaling Peptides and Proteins/deficiency/genetics/*metabolism ; Lymphopenia/genetics/pathology ; Mice ; Models, Genetic ; Receptors, Antigen, T-Cell/genetics/metabolism ; *Recombination, Genetic ; Sequence Homology ; T-Lymphocytes/cytology/metabolism ; Thymus Gland/cytology
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 2
    Publication Date: 2016-03-26
    Description: The climatic variability hypothesis posits that the magnitude of climatic variability increases with latitude, elevation, or both, and that greater variability selects for organisms with broader temperature tolerances, enabling them to be geographically widespread. We tested this classical hypothesis for the elevational range sizes of more than 16,500 terrestrial vertebrates on 180 montane gradients. In support of the hypothesis, mean elevational range size was positively correlated with the scope of seasonal temperature variation, whereas elevational range size was negatively correlated with daily temperature variation among gradients. In accordance with a previous life history model and our extended versions of it, our findings indicate that physiological specialization may be favored under shorter-term climatic variability.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chan, Wei-Ping -- Chen, I-Ching -- Colwell, Robert K -- Liu, Wei-Chung -- Huang, Cho-Ying -- Shen, Sheng-Feng -- New York, N.Y. -- Science. 2016 Mar 25;351(6280):1437-9. doi: 10.1126/science.aab4119.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Biodiversity Research Center, Academia Sinica, Taipei 11529, Taiwan. ; Biodiversity Research Center, Academia Sinica, Taipei 11529, Taiwan. Department of Life Sciences, National Cheng Kung University, Tainan 70101, Taiwan. ; Department of Ecology and Evolutionary Biology, University of Connecticut, Storrs, CT 06269, USA. University of Colorado Museum of Natural History, Boulder, CO 80309, USA. Departmento de Ecologia, Universidade Federal de Goias, CP 131, 74.001-970 Goiania, Goias, Brazil. ; Institute of Statistical Science, Academia Sinica, Taipei 11529, Taiwan. ; Department of Geography, National Taiwan University, Taipei 10617, Taiwan. ; Biodiversity Research Center, Academia Sinica, Taipei 11529, Taiwan. shensf@sinica.edu.tw.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/27013729" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Climate ; *Global Warming ; *Seasons ; *Temperature ; Vertebrates/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
    Publication Date: 2023-06-27
    Keywords: CALYPSO; Calypso Corer; Counting; DEPTH, sediment/rock; Globigerina bulloides; Globigerina digitata; Globigerina falconensis; Globigerina rubescens; Globigerinella aequilateralis; Globigerinella calida; Globigerinita glutinata; Globigerinoides conglobatus; Globigerinoides ruber; Globigerinoides sacculifer; Globigerinoides tenellus; Globoquadrina conglomerata; Globorotalia crassaformis; Globorotalia inflata; Globorotalia menardii; Globorotalia scitula; Globorotalia truncatulinoides dextral; Globorotalia truncatulinoides sinistral; IMAGES; IMAGES III - IPHIS; International Marine Global Change Study; Marion Dufresne (1995); MD106; MD972151; MD97-2151; Neogloboquadrina dutertrei; Neogloboquadrina pachyderma sinistral; Orbulina universa; Pulleniatina obliquiloculata; South China Sea; Sphaeroidinella dehiscens
    Type: Dataset
    Format: text/tab-separated-values, 7521 data points
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