Publication Date:
1991-10-25
Description:
The production and functional activity of two important white blood cells, the granulocytes and macrophages, are regulated mainly by a group of glycoprotein colony-stimulating factors. The colony-stimulating factors have been mass-produced with recombinant technology and are now proving of value in preventing or suppressing infections in a variety of individuals with subnormal or defective formation of blood cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Metcalf, D -- New York, N.Y. -- Science. 1991 Oct 25;254(5031):529-33.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Walter and Eliza Hall Institute of Medical Research, Post Office Royal Melbourne Hospital, Victoria, Australia.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1948028" target="_blank"〉PubMed〈/a〉
Keywords:
Acquired Immunodeficiency Syndrome/therapy
;
Anemia, Aplastic/therapy
;
Animals
;
Colony-Stimulating Factors/genetics/*physiology/therapeutic use
;
Granulocytes/cytology/*physiology
;
Hematopoiesis
;
Hematopoietic Stem Cells/cytology/*physiology
;
Humans
;
Macrophages/cytology/*physiology
;
Mice
;
Neoplasms/therapy
;
Neutropenia/therapy
;
Recombinant Proteins/therapeutic use
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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