Publication Date:
1985-07-05
Description:
The granulocyte-macrophage colony-stimulating factors are well-characterized specific glycoproteins that interact to control the production, differentiation, and function of two related white cell populations of the blood, the granulocytes and monocyte-macrophages. Widely produced in the body, these regulators probably play an important role in resistance to infections. The proliferation of myeloid leukemia cells remains dependent on stimulation by colony-stimulating factors, although one of them also has the ability to suppress leukemic populations by inducing terminal differentiation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Metcalf, D -- CA-22556/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1985 Jul 5;229(4708):16-22.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2990035" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Bone Marrow Cells
;
Cell Differentiation
;
Cell Division
;
Cell Survival
;
Cloning, Molecular
;
Colony-Stimulating Factors/*physiology
;
Granulocytes/*physiology
;
*Hematopoiesis
;
Humans
;
Leukemia, Myeloid, Acute/physiopathology
;
Macrophages/*physiology
;
Mice
;
Molecular Weight
;
Receptors, Cell Surface/physiology
;
Receptors, Colony-Stimulating Factor
;
Species Specificity
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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