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  • LUNAR AND PLANETARY EXPLORATION  (8)
  • Anaphase-Promoting Complex-Cyclosome  (3)
  • 1
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    Identification of a cullin homology region in a subunit of the anaphase-promoting complex (1998)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1998-03-21
    Description: The anaphase-promoting complex is composed of eight protein subunits, including BimE (APC1), CDC27 (APC3), CDC16 (APC6), and CDC23 (APC8). The remaining four human APC subunits, APC2, APC4, APC5, and APC7, as well as human CDC23, were cloned. APC7 contains multiple copies of the tetratrico peptide repeat, similar to CDC16, CDC23, and CDC27. Whereas APC4 and APC5 share no similarity to proteins of known function, APC2 contains a region that is similar to a sequence in cullins, a family of proteins implicated in the ubiquitination of G1 phase cyclins and cyclin-dependent kinase inhibitors. The APC2 gene is essential in Saccharomyces cerevisiae, and apc2 mutants arrest at metaphase and are defective in the degradation of Pds1p. APC2 and cullins may be distantly related members of a ubiquitin ligase family that targets cell cycle regulators for degradation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yu, H -- Peters, J M -- King, R W -- Page, A M -- Hieter, P -- Kirschner, M W -- CA16519/CA/NCI NIH HHS/ -- GM26875-17/GM/NIGMS NIH HHS/ -- GM39023-08/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1998 Feb 20;279(5354):1219-22.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9469815" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; *Anaphase ; Anaphase-Promoting Complex-Cyclosome ; Animals ; Apc1 Subunit, Anaphase-Promoting Complex-Cyclosome ; Apc2 Subunit, Anaphase-Promoting Complex-Cyclosome ; Apc4 Subunit, Anaphase-Promoting Complex-Cyclosome ; Apc5 Subunit, Anaphase-Promoting Complex-Cyclosome ; Apc7 Subunit, Anaphase-Promoting Complex-Cyclosome ; Apc8 Subunit, Anaphase-Promoting Complex-Cyclosome ; Cell Cycle/*physiology ; Cell Cycle Proteins/chemistry ; Cloning, Molecular ; *Cullin Proteins ; Helminth Proteins/chemistry ; Humans ; Ligases/*chemistry/genetics/metabolism ; Molecular Sequence Data ; Mutation ; Open Reading Frames ; Phylogeny ; Proteins/chemistry ; Saccharomyces cerevisiae/chemistry/cytology/genetics ; *Saccharomyces cerevisiae Proteins ; Sequence Alignment ; *Ubiquitin-Protein Ligase Complexes ; Ubiquitin-Protein Ligases
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Ubistatins inhibit proteasome-dependent degradation by binding the ubiquitin chain (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-10-02
    Description: To identify previously unknown small molecules that inhibit cell cycle machinery, we performed a chemical genetic screen in Xenopus extracts. One class of inhibitors, termed ubistatins, blocked cell cycle progression by inhibiting cyclin B proteolysis and inhibited degradation of ubiquitinated Sic1 by purified proteasomes. Ubistatins blocked the binding of ubiquitinated substrates to the proteasome by targeting the ubiquitin-ubiquitin interface of Lys(48)-linked chains. The same interface is recognized by ubiquitin-chain receptors of the proteasome, indicating that ubistatins act by disrupting a critical protein-protein interaction in the ubiquitin-proteasome system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Verma, Rati -- Peters, Noel R -- D'Onofrio, Mariapina -- Tochtrop, Gregory P -- Sakamoto, Kathleen M -- Varadan, Ranjani -- Zhang, Mingsheng -- Coffino, Philip -- Fushman, David -- Deshaies, Raymond J -- King, Randall W -- CA78048/CA/NCI NIH HHS/ -- GM068276/GM/NIGMS NIH HHS/ -- GM65334/GM/NIGMS NIH HHS/ -- GM66492/GM/NIGMS NIH HHS/ -- P50 CA92131/CA/NCI NIH HHS/ -- R01 GM-45335/GM/NIGMS NIH HHS/ -- R21CA108545/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 2004 Oct 1;306(5693):117-20.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biology, Howard Hughes Medical Institute (HHMI), California Institute of Technology, Pasadena, CA 91125, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15459393" target="_blank"〉PubMed〈/a〉
    Keywords: Anaphase-Promoting Complex-Cyclosome ; Animals ; Cell Extracts ; Cyclin B/metabolism ; Cyclin-Dependent Kinase Inhibitor Proteins ; Cysteine Endopeptidases/metabolism ; *Drug Evaluation, Preclinical ; Interphase ; Mitosis ; Molecular Structure ; Multienzyme Complexes/*antagonists & inhibitors/metabolism ; Ornithine Decarboxylase/metabolism ; Proteasome Endopeptidase Complex ; Protein Binding ; Proteins/*metabolism ; Quinolines/*metabolism/pharmacology ; Recombinant Fusion Proteins ; Saccharomyces cerevisiae Proteins/metabolism ; Sulfanilic Acids/*metabolism/pharmacology ; Ubiquitin/*metabolism ; Ubiquitin-Protein Ligase Complexes/metabolism ; Xenopus laevis
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    How proteolysis drives the cell cycle (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1996-12-06
    Description: Oscillations in the activity of cyclin-dependent kinases (CDKs) promote progression through the eukaryotic cell cycle. This review examines how proteolysis regulates CDK activity-by degrading CDK activators or inhibitors-and also how proteolysis may directly trigger the transition from metaphase to anaphase. Proteolysis during the cell cycle is mediated by two distinct ubiquitin-conjugation pathways. One pathway, requiring CDC34, initiates DNA replication by degrading a CDK inhibitor. The second pathway, involving a large protein complex called the anaphase-promoting complex or cyclosome, initiates chromosome segregation and exit from mitosis by degrading anaphase inhibitors and mitotic cyclins. Proteolysis therefore drives cell cycle progression not only by regulating CDK activity, but by directly influencing chromosome and spindle dynamics.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉King, R W -- Deshaies, R J -- Peters, J M -- Kirschner, M W -- New York, N.Y. -- Science. 1996 Dec 6;274(5293):1652-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cell Biology, Harvard Medical School, 240 Longwood Ave., Boston, MA 02115, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8939846" target="_blank"〉PubMed〈/a〉
    Keywords: Anaphase ; Anaphase-Promoting Complex-Cyclosome ; Animals ; *Cell Cycle ; Cell Cycle Proteins/metabolism ; Cell Division ; Cyclin-Dependent Kinases/antagonists & inhibitors/*metabolism ; Cyclins/metabolism ; Enzyme Inhibitors/metabolism ; Fungal Proteins/metabolism ; Fungi/cytology/metabolism ; G1 Phase ; Humans ; Ligases/metabolism ; Mitosis ; Proteins/*metabolism ; S Phase ; Ubiquitin-Conjugating Enzymes ; *Ubiquitin-Protein Ligase Complexes ; Ubiquitin-Protein Ligases ; Ubiquitins/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Numerical model of the moon's rotation (1981)
    In:  Other Sources
    Details
    Publication Date: 2019-06-28
    Description: The differential equations for the Euler angles that define the moon's orientation with respect to an inertial coordinate frame have been integrated numerically. This numerical model of the moon's rotation, when used in conjunction with current lunar-orbit and earth-rotation models, fits lunar laser ranging observations over a five-year period within 28 cm (rms). The present model is also compared with the numerical model of Williams (1975) and Eckhardt's (1981) semianalytical model.
    Keywords: LUNAR AND PLANETARY EXPLORATION
    Type: Moon and the Planets; 24; May 1981
    Format: text
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  • 5
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    Tidal dissipation in the moon (1981)
    In:  Other Sources
    Details
    Publication Date: 2019-06-28
    Description: Euler's equations of motion, modified to include elasticity and solid friction, were used to study the rotation of the moon. Two heuristic models for the anelasticity were considered: Q independent of frequency and Q inversely proportional to the frequency and Q inversely proportional to the frequency of the strain oscillation. Parameters in each model were estimated by weighted least squares from 9 years of lunar laser range observations. The root mean square of the postfit range residuals was 19 cm in each case. For a strain period of 1 month, the estimates of Q obtained with the two models were similar and surprisingly low: 23 + or - 6. The range of uncertaintly, + or - 6, represents our estimate of the true standard deviation of the estimate of Q, as affected by systematic errors; it is 3 times larger than the formal, statistical, standard error.
    Keywords: LUNAR AND PLANETARY EXPLORATION
    Type: Journal of Geophysical Research; 86; Aug. 10
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  • 6
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    Zonal and meridional circulation of the lower atmosphere of Venus determined by radio interferometry (1980)
    In:  Other Sources
    Details
    Publication Date: 2019-06-28
    Description: The results of the Pioneer Venus differential long-baseline interferometry experiment are presented. The velocity component of the Pioneer probes as they fell to the surface of Venus was calculated from the Doppler shift of the received signal, and the other two orthogonal components were determined by long-baseline interferometry. The ambient wind velocity was about 1 m/s or less near the surface of the planet and about 100 m/s at an altitude of about 65 km at all four probe locations. Strata of high wind shear were found at altitudes of 15, 45, and 60 km. The wind velocity was always directed within a few degrees of due west except at a few km above the surface. The dominant motion of the lower atmosphere seems to be a retrograde zonal rotation, and eddies appear to account for most of the instantaneous meridional velocity. The data suggest that, within the clouds, a thermally driven mean meridional circulation is superimposed upon the much more rapid zonal rotation.
    Keywords: LUNAR AND PLANETARY EXPLORATION
    Type: Journal of Geophysical Research; 85; Dec. 30
    Format: text
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  • 7
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    The rotation of Mars (1979)
    In:  Other Sources
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    Publication Date: 2019-06-27
    Description: A new model of the rotation of Mars is presented that is designed to support the analysis of radio metric data from the Viking landers and possible future Mars-lander missions. The precession and nutation are represented by series that include all terms causing a maximum Mars surface displacement of at least 1 cm after 10 years. The precession rate is estimated from Mars physical constants to be (7.58 in. + or - 0.03 in.)/yr based on Reasenberg's (1977) model of the mass distribution of Mars. Some geophysical effects that may cause Mars surface displacements larger than 1-cm criterion are also discussed.
    Keywords: LUNAR AND PLANETARY EXPLORATION
    Type: Journal of Geophysical Research; 84; Oct. 10
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  • 8
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    Venus winds are zonal and retrograde below the clouds (1979)
    In:  Other Sources
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    Publication Date: 2019-06-27
    Description: Winds in the lower atmosphere of Venus, inferred from three-dimensional radio interferometric tracking of the descents of the Pioneer day and north probes, are predominantly easterly with speeds of about 1 M/sec near the surface, 50 at the bottom of the clouds, and more than 200 within the densest, middle cloud layer. Between about 25 and 55 km altitude the average flow was slanted equatorward, with superimposed wavelike motions and alternating layers of high and low shear
    Keywords: LUNAR AND PLANETARY EXPLORATION
    Type: Science; 205; July 6
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  • 9
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    Precision Selenodesy via Differential Very-Long-Baseline Interferometry (1975)
    In:  CASI
    Details
    Publication Date: 2019-06-27
    Description: The technique of differential very-long baseline interferometry was used to measure the relative positions of the ALSEP transmitters at the Apollo 12, 14, 15, 16, and 17 lunar landing sites with uncertainties less than 0.005 of geocentric arc. These measurements yielded improved determinations of the selenodetic coordinates of the Apollo landing sites, and of the physical libration of the moon. By means of a new device, the differential Doppler receiver (DDR), instrumental errors were reduced to less than the equivalent of 0.001. DDRs were installed in six stations of the NASA spaceflight tracking and data network and used in an extensive program of observations beginning in March 1973.
    Keywords: LUNAR AND PLANETARY EXPLORATION
    Type: NASA-CR-143452
    Format: application/pdf
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  • 10
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    Study of lunar librations using differential very-long-baseline observations of ALSEPs (1977)
    In:  Other Sources
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    Publication Date: 2019-06-27
    Description: Observations of signals from the ALSEP transmitters via differential very-long-baseline interferometry (VLBI) are being made to determine the relative selenocentric coordinates of the ALSEPs and the motion of the moon about its center of mass. By VLBI the relative positions of the ALSEPs can be determined with uncertainties less than 5 meters, and the orientation of the moon within 0.5 second of selenocentric arc.
    Keywords: LUNAR AND PLANETARY EXPLORATION
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