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  • 1
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    Pharmacologic effects in man of a specific serotonin-reuptake inhibitor (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-01-27
    Description: Fluoxetine (Li-ly 110140) caused a 63 percent inhibition of [3H]serotonin uptake into platelets obtained from normal volunteers to whom the drug was administered daily for 7 days. This dose had no effect on the usual pressor response produced by injections of norepinephrine or tyramine.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lemberger, L -- Rowe, H -- Carmichael, R -- Oldham, S -- Horng, J S -- Bymaster, F P -- Wong, D T -- New York, N.Y. -- Science. 1978 Jan 27;199(4327):436-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/619465" target="_blank"〉PubMed〈/a〉
    Keywords: Behavior/drug effects ; Blood Platelets/*drug effects/metabolism ; Blood Pressure/drug effects ; Humans ; Norepinephrine/pharmacology ; Phenyl Ethers/pharmacology ; Propylamines/*pharmacology ; Serotonin/*blood ; Serotonin Antagonists/pharmacology ; Tyramine/pharmacology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
    Electronic Resource
    Electronic Resource
    The effect of crystal size on the bioavailability of benoxaprofen: Studies utilizing deuterium labeled drug (1979)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 6 (1979), S. 173-178 
    Details
    ISSN: 0306-042X
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A study of the effect of crystal size on the bioavailability of benoxaprofen, 2-[4-chlorophenyl]-α-methyl-5-benzoxazoleacetic acid, in man is reported. The technique utilized comparison of either the plasma concentrations or urine levels, resulting from administration of deuterium labeled (2H7) drug in solution coadministered with a test capsule formulation. Drug concentrations were determined by gas chromatography, and the ratio of labeled to unlabeled drug was obtained by gas chromatography mass spectrometry. Measurements following coadministration of labeled and unlabeled drug in solution established the absence of an isotope effect due to the presence of deuterium. The dry formulations consisted of either a 3.17-100 micron fraction (mean = 18.5 microns) or a 32-1000 micron fraction (mean = 610 microns) formulated with starch powder. The results in three subjects indicate an almost complete availability (0.95-0.98) of the small crystals as measured by comparison of either area under the plasma level curves or urine excretion (0.94-0.97) of labeled versus unlabeled drug measured to 168 hours. The larger crystals exhibited a lower availability as shown by plasma levels (0.41-0.46) or urine recovery (0.39-0.43). A higher dose of the large crystal formulation resulted in decreased relative availability with a fourfold dose dropping availability to 0.22 in a single subject.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200060409
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