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  • Chemistry  (46)
  • Meteorology and Climatology  (16)
  • Analytical Chemistry and Spectroscopy  (13)
  • BSSA  (13)
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  • 1
    Electronic Resource
    Electronic Resource
    Radical polymerization of mono- and di-methacrylic esters containing bisphenol-S (1993)
    Weinheim : Wiley-Blackwell
    Angewandte Makromolekulare Chemie 207 (1993), S. 43-52 
    Details
    ISSN: 0003-3146
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Description / Table of Contents: Die radikalische Polymerisation von Bisphenol-S enthaltenden Mono- und Dimethacrylsaureestern (BPS-M und BPS-DM) wurde bezüglich Polymerisationsgeschwindigkeit, Läsungsmitteleinfluß, Copolymerisation und Kinetik der Photovernetzung untersucht. Es zeigte sich, daß das Lösungsmittel die Polymerisationsgeschwindigkeit signifikant beeinflußt; polare Lösungsmittel wie DMSO und Acetonitril verlangsamen die Polymerisationsgeschwindigkeit. Die Copolymerisation von BPS-M (M1) mit MMA (M1) wurde in Aceton bei 60°C untersucht. Die Copolymerisationsparameter wurden nach der Fineman-Ross-Methode zu r1 = 3,72 ± 0,0l und r2 = 0,80 ± 0,0l berechnet. Die hohe Reaktivität von BPS-M in diesem Copolymerisationssystem kann vermutlich dem „Matrix-Effekt“ zugeschrieben werden. Funktionelle Polymere mit Methacrylat- Seitengruppen wurden erfolgreich modifiziert und durch Bestrahlung in Gegenwart von Benzoinisopropylether photovernetzt. Die Kinetik der Photovernetzung ist zweiter Ordnung.
    Notes: Radical polymerizations of mono- and di-methacrylic esters containing bisphenol-S (BPS-M and BPS-DM) were studied in terms of polymerization rate, solvent effect, copolymerization and kinetic measurements of photocrosslinking. The solvents were found to affect significantly the polymerization rate. Polar solvents such as DMSO and acetonitrile were found to slow down the polymerization rate. Copolymerization of BPS-M(M1) with MMA(M2) was studied in acetone at 60°C. The monomer reactivity ratios were calculated to be r1 = 3.72 ± 0.01 and r2 = 0.80 ± 0.01 by the Fineman-Ross method. The high reactivity of BPS-M observed in this copolymerization system may be due to the “matrix effect”. Functional polymers containing methacrylate side-groups were successfully modified and photocrosslinked by irradiation in the presence of benzoin isopropyl ether. The photocrosslinking process is found to be of second order kinetics.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/apmc.1993.052070105
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  • 2
    Electronic Resource
    Electronic Resource
    Synthesis and Evaluation of 2-{[(2-Oxo-1H-quinolin-8-yl)oxy]methyl}-Substituted α-Methylidene-γ-butyrolactones (1997)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 80 (1997), S. 1161-1168 
    Details
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: O-Alkylation of 8-hydroxy-1H-quinolin-2-one (1) afforded 8-(2-oxopropoxy)-1H-quinolin-2-one (2) which was immediately cyclized to form the tricyclic 2,3-dihydro-3-hydroxy-3-methyl-5H-pyrido[1,2,3-de][1,4]benzoxazine,-5-one (3). The Reformatsky-type condensation of 3 furnished antiplatelet 8-[(2,3,4,5-tetrahydro-2-methyl-4-methylidene-5-oxofuran-2-yl)melhoxy]-1H-quinolin-2-one (4). Its counterparts 7a-f, Ph-substituted at C(2) of the furan ring, were obtained from 1 via alkylation and the Reformatsky-type condensation. Although compound 4 was less active against platelet aggregation than 7a-f, it was the only compound which exhibited significant inhibitory activity on high-K+ medium, Ca2+-induced vasoconstriction and was more active than most of its Ph-substituted counterparts against norepinephrine-induced vasoconstrictions.
    Additional Material: 3 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/hlca.19970800413
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  • 3
    Electronic Resource
    Electronic Resource
    α-Methylidene-γ-butyrolactones: Synthesis and evaluation of quinolin-2(1H)-one derivatives (1998)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 81 (1998), S. 1038-1047 
    Details
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: As a continuation of our previous studies on the synthesis and antiplatelet activity of quinolin-2(1H)-ones with an α-methylidene-γ-butyrolactone substituted at O(8), the O(6)- and N(1)-substituted isomers were synthesized and evaluated for antiplatelet activity against thrombin (Thr)-, arachidonic acid (AA)-, collagen (Col)-, and platelet-activating-factor (PAF)-induced aggregation in washed rabbit platelets. These compounds were synthesized from 6-hydroxyquinolin-2(1H)-one via alkylation and Reformatsky-type condensation (Schemes 1 and 2). All of them were found to inhibit the platelet aggregation perfectly which was induced by AA and Col. 6-Substituted isomers 5b-g exhibited very strong inhibitory activities against AA- and PAF- induced aggregation and are approximately ten times more potent than their 8-substituted counterparts. However, the 1-substituted (11a and 11b) and the 1,6-disubstituted (6) counterparts were relatively inactive. Their effects on the Ca2+-dependent vasoconstriction induced by high K+, and the phasic and tonic vasoconstrictions induced by norepinephrine (NE) in rat aorta were also evaluated. Except 5g, all of them were found to have significant inhibitory activity on the NE-induced phasic and tonic vasoconstrictions. Compounds 6 and 11b also exhibited strong inhibitory activity on high-K+ medium, Ca2+-induced vasoconstriction.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/hlca.19980810517
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  • 4
    Electronic Resource
    Electronic Resource
    Synthesis of Coumarin Derivatives as Inhibitors of Platelet Aggregation (1996)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 79 (1996), S. 651-657 
    Details
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: In a search for the inhibitors of platelet aggregation, certain coumarin derivatives were synthesized and evaluated for antiplatelet activity against thrombin(Thr)-, arachidonic acid(AA)-, collagen(Col)-, and platelet-activating-factor(PAF)-induced aggregation in washed rabbit platelets. These compounds were synthesized from 4-hydroxycoumarin (1) or naphthalen-1-ol via alkylation and Reformatsky-type condensation (Schemes 1-3). Among them, 4-[(2,3,4,5-tetrahydro-4-methylidene-5-oxo-2-phenylfuran-2-yl)methoxy]-2H-1-benzopyran-2-one (6b) showed potent antiplatelet effects on AA- and PAF-induced aggregation with IC50 values of 8.21 and 103.67 m̈M, respectively (see Tables 1 and 2). The antiplatelet potency of 6b against PAF-induced aggregation could be further improved by introducing a proper substituent at the 2-phenyl group of the lactone ring.
    Additional Material: 2 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/hlca.19960790308
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  • 5
    Electronic Resource
    Electronic Resource
    Antiplatelet α-Methylidene-γ-butyrolactones: Synthesis and evaluation of quinoline, flavone, and xanthone derivatives (1996)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 79 (1996), S. 1620-1626 
    Details
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: As a continuation of our previous studies on the synthesis and antiplatelet activity of coumarin derivatives of α-methylidene-γ-butyrolactones, certain quinoline, flavone, and xanthone derivatives were synthesized and evaluated for antiplatelet activity against thrombin (Thr)-, arachidonic acid (AA)-, collagen (Col)-, and platelet-activating factor (PAF)-induced aggregation in washed rabbit platelets. These compounds were synthesized from quinolin-8-ol, flavon-7-ol, and xanthon-3-ol, respectively, via alkylation and Reformatsky-type condensation (Schemes 1-3). By the comparison with comparison with coumarin α-methylidene-γ-butyrolactone 3a, flavone and xanthone derivatives, 3b and 3c, respectively, are more selective in which only AA- and collagen-induced aggregation are strongly inhibited. Most of the quinoline derivatives (9a-e) exhibited broad-spectrum antiplatelet activities.
    Additional Material: 2 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/hlca.19960790612
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  • 6
    Electronic Resource
    Electronic Resource
    Synthesis and Evaluation of α-Methylidene-γ-butyrolactone bearing flavone and xanthone moieties (1997)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 80 (1997), S. 2337-2344 
    Details
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: In a search for inhibitors of platelet aggregation, a number of α-methylidene-γ-butyrolactones 5 and 6 bearing flavone or xanthone moieties, respectively, were synthesized and evaluated for their antiplatelet activity against thrombin(Thr)-, arachidonic-acid(AA)-, collagen(Col)-, and platelet-activating-factor(PAF)-induced aggregation in washed rabbit platelets. These compounds were synthesized from 7-hydroxyflavone (1) or 3-hydroxyxanthone (2) via O-alkylation (→ 3 and 4, resp.) and Reformatsky-type condensation (Scheme). Most of the flavone-containing α-methylidene-γ-butyrolactones 5a-d showed potent antiplatelet effects on AA- and Col-induced aggregation, while xanthone derivatives 6c-e were found to have the same pharmacological profile than aspirin in which only AA-induced aggregation was inhibited (Table 1). However, 6c-e were approximately three to ten times more potent than aspirin (Table 2). For the vasorelaxing effects, 5a was the only compound which exhibited significant inhibitory activity on the high-K+ medium, Ca2+-induced vasoconstriction (Table3). Both 5a and 6a, with an aliphatic Me substituent at C(γ) of the lactone, were active against norepinephrine-induced phasic and tonic constrictions while their γ-aryl-substituted counterparts 5b-f and 6b-f were inactive.
    Additional Material: 3 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/hlca.19970800806
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  • 7
    Electronic Resource
    Electronic Resource
    Photodimerization and photopolymerization of amphiphilic cinnamic acid derivatives in oriented monolayers, vesicles and solution (1986)
    New York : Wiley-Blackwell
    Die Makromolekulare Chemie 187 (1986), S. 1843-1853 
    Details
    ISSN: 0025-116X
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: Cinnamic acid moieties were incorporated into amphiphilic compounds containing one and two alkyl chains. These lipid-like compounds with photoreactive units undergo self-organization to form monolayers at the gas-water interface and bilayer structures (vesicles) in aqueous solutions. The photoreaction of the cinnamic acid moiety induced by 254 nm UV light was investigated in the crystalline state, in monolayers, in vesicles and in solution in organic solvents. The single-chain amphiphiles undergo dimerization to yield photoproducts with twice the molecular weight of the corresponding monomers in organized systems. The photoreaction of amphiphiles containing two cinnamic acid groups occurs via two mechanisms: The intramolecular dimerization produces bicycles, with retention of the molecular weight of the corresponding monomer. The intermolecular reaction leads to oligomeric and polymeric photoproducts. In contrast to the single-chain amphiphiles, photodimerization processes of lipoids containing two cinnamic acid moieties also occur in solution in organic solvents.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/macp.1986.021870804
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  • 8
    Electronic Resource
    Electronic Resource
    N-substituted methacrylamide copolymers. Novel membranous material for carbon kidneyDedicated to Prof. Dr. T. Tsuruta on the occasion of his 65th birthday (1985)
    New York : Wiley-Blackwell
    Die Makromolekulare Chemie 186 (1985), S. 2461-2471 
    Details
    ISSN: 0025-116X
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: Copolymers of N-substituted methacrylamide (1a, b), new biomaterials, were synthesized to be used as encapsulating membranes of carbon kidney. In order to obtain a copolymer with a suitable hydrophilic property, the aminolysis of styrene-methyl methacrylate (St-MMA) copolymer with N-(2-hydroxyethyl)ethylenediamine was carried out under various conditions. The occurrence of aminolysis was confirmed by elemental analysis, IR and 1H NMR spectra. It was shown that a copolymer of N-substituted methacrylamide with a predictable degree of hydrophilicity can be obtained by controlling the composition ratio of the St-MMA copolymer and the degree of aminolysis of the copolymer. Hemoperfusion experiments with a living animal (dog), using a minicolumn with several types of microspheric activated carbon encapsulated with various copolymers, showed that copolymers with suitable hydrophilicity and hydrophobicity or with proper structure have a good blood compatibility. Studies with creatinine, uric acid and vitamin B12 showed that microspheric activated carbon, encapsulated with N-substituted methacrylamide copolymers of proper hydrophilicity and structure, has a good penetration property, and that detaching of activated carbon particles is effectively prevented.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/macp.1985.021861206
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  • 9
    Electronic Resource
    Electronic Resource
    Mechanism and evaluation in electroinitiated copolymerization coatings of acrylonitrile and acrylic acid (1979)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 23 (1979), S. 101-113 
    Details
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Adherent films of copolymers on different metal surfaces were formed by an electrolytically initiated polymerization of acrylonitrile (AN) and acrylic acid (AA) in 0.05N H2SO4 aqueous solution. The electrolysis was carried out under a constant current. Hydrogen overvoltages for five different metals used as the cathode were measured in order to interpret the nature and quality of the coating. Solutions containing varying volume fractions of AN and containing different electrolytes gave rise to coatings of varying film thickness. Based on the analyses of copolymer compositions, it is believed that the polymer was formed at the cathode by a free-radical propagation mechanism. The film hardness and the adhesion between the polymer and the metal surface were measured with an Arco microknife. Furthermore, the scanning electron microscope (SEM) was used to examine the structure of the film surface and cross section. The corrosion rates of the coated and uncoated metals in substitute ocean water were also measured for purposes of evaluation of the coatings.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/app.1979.070230109
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  • 10
    Electronic Resource
    Electronic Resource
    Fast atom bombardment mass spectrometric investigation of in vitro degradation within the disulfide-linked core of atrial natriuretic factor (1989)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 18 (1989), S. 12-19 
    Details
    ISSN: 0887-6134
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The use of high-performance liquid chromatography and fast atom bombardment mass spectrometry are shown to be an efficient combination for investigating protease-mediated digestion of synthetic analogs of the peptide hormone ANF (atrial natriuretic factor). As examples of the reported methodology, rANF5-23-NH2 and rANF7-23-NH2 were digested with the endopeptidase thermolysin. These truncated analogs were selected to investigate metabolism within the disulfide-linked core of ANF, particularly at the Cys7—Phe8 bond. While this position was the site of initial hydrolysis for rANF5-23-NH2 (t1/2 = 0.5 min), the Cys7—Phe8 bond remained intact for all observed degradation products of rANF7-23-NH2 (t1/2 = 16 min). These findings suggest that improved stability towards endopeptidase-mediated core hydrolysis may be conferred to analogs of ANF by removal of the first six residues from the N-terminus.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200180104
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