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  • 1
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    Reduction of morphine abstinence in mice with a mutation in the gene encoding CREB (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1996-08-02
    Description: Chronic morphine administration induces an up-regulation of several components of the cyclic adenosine 5'-monophosphate (cAMP) signal transduction cascade. The behavioral and biochemical consequences of opiate withdrawal were investigated in mice with a genetic disruption of the alpha and Delta isoforms of the cAMP-responsive element-binding protein (CREB). In CREBalphadelta mutant mice the main symptoms of morphine withdrawal were strongly attenuated. No change in opioid binding sites or in morphine-induced analgesia was observed in these mutant mice, and the increase of adenylyl cyclase activity and immediate early gene expression after morphine withdrawal was normal. Thus, CREB-dependent gene transcription is a factor in the onset of behavioral manifestations of opiate dependence.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Maldonado, R -- Blendy, J A -- Tzavara, E -- Gass, P -- Roques, B P -- Hanoune, J -- Schutz, G -- New York, N.Y. -- Science. 1996 Aug 2;273(5275):657-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Departement de Pharmacochimie Moleculaire et Structurale, Unite de Recherche Associee D1500 CNRS, Universite Rene Descartes, Faculte de Pharmacie, Paris, France.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8662559" target="_blank"〉PubMed〈/a〉
    Keywords: Adenylyl Cyclases/metabolism ; Analgesia ; Animals ; Behavior, Animal ; Cerebral Cortex/enzymology ; Cyclic AMP Response Element-Binding Protein/*genetics/*physiology ; Drug Tolerance ; Gene Expression Regulation ; Gene Targeting ; Genes, Immediate-Early ; Locus Coeruleus/metabolism ; Mice ; Morphine/*administration & dosage/adverse effects/pharmacology ; Morphine Dependence/*etiology/metabolism ; Mutation ; Naloxone/pharmacology ; Receptors, Opioid/metabolism ; Signal Transduction ; Substance Withdrawal Syndrome/*physiopathology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
    Electronic Resource
    Electronic Resource
    Pre-and post-natal ontogeny of neutral endopeptidase 24-11 (‘enkephalinase’) studied by in vitro autoradiography in the rat (1992)
    Springer
    Cellular and molecular life sciences 48 (1992), S. 290-300 
    Details
    ISSN: 1420-9071
    Keywords: Neutral endopeptidase (NEP) ; enkephalinase ; CALLA ; NEP inhibitor ; [3H]HACBO-Gly ; autoradiography ; atrial natriuretic peptide
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Neutral endopeptidase (NEP, enkephalinase, CALLA) which is present in various neural and non-neural tissues, is able to cleave a variety of regulatory peptides. The distribution of NEP has been studied during rat pre-and post-natal development by autoradiography after in vitro binding of the tritiated inhibitor [3H]HACBO-Gly to whole-body and organ sections. In the central nervous system (CNS), where the presence of NEP has been related to the termination of the action of enkephalins, the external layer of the olfactory bulbs is the only structure prominently labeled before birth. Other CNS structures rich in NEP in the adult, such as the nigrostriatal tract, are progressively labeled after birth. Outside the CNS, the progressive appearance of NEP in the kidney, the lungs and the salivary glands suggests its concomitant involvement in adult physiological functions, including fluid balance control, possibly by cleaving the atrial natriuretic peptide (ANP) and other peptides. On the other hand, transient or enhanced expression of NEP is observed during the development of several organs such as the sensory organs, the heart and the major blood vessels, the intestine, the bones and the genital tubercle. In addition to the still incompletely known physiological functions of the enzyme, the developmental pattern of its expression in several tissues strongly suggests a modulatory role for NEP in the ontogeny of a large number of organs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01930479
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