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  • Saccharomonospora viridis  (2)
  • Amphotericin B  (1)
  • 1
    ISSN: 1573-0832
    Keywords: Amphotericin B ; Epididymal histoplasmosis ; Histoplasma capsulatum ; Semen culture
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract An autochthonous case of epididymal histoplasmosis masquerading as tuberculosis in a 55-year-old male patient is reported from India. It was diagnosed by culture ofHistoplasma capsulatum from semen and by demonstration of the fungus upon re-examination of epididymal biopsy sections previously misinterpreted as tuberculous granuloma. The patient's main complaints were painful epididymal swelling, occasional fever and cough. He was treated successfully by excision of epididymis and vas deferens combined with amphotericin B therapy. This is believed to be the first case of epididymal histoplasmosis to be reported outside the American continent and the fourth of its type reported in the English literature. The case is also noteworthy in thatH. capsulatum was isolated for the first time from semen, and it underlines the importance of mycological culture of semen specimens for diagnosis of genitourinary infections of obscure etiology.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1572-9699
    Keywords: thermophilic actmonycetes in India ; Faenia rectivirgula ; Thermoactinomyces spp. ; Saccharomonospora viridis ; hay ; compost ; bagasse ; soil ; straw
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Medically important thermophilic actinomycetes were isolated from 218 (64%) of 341 samples of vegetable substrates and soil examined from sites in north-western India. Thermoactinomyces vulgaris (T. candidus) was the commonest species, occurring in 56% of samples, followed by Saccharomonospora viridis in 29%, Thermoactinomyces thalpophilus in 27%, Faenia rectivirgula (Micropolyspora faeni) in 21% and Thermoactinomyces sacchari in 14%. T. vulgaris and T. thalpophilus were isolated from all types of substrate examined, with T. vulgaris always more common than T. thalpophilus. Of the other thermophilic actinomycetes, F. rectivirgula was isolated predominantly from hay (44%) and S. viridis (56%) and T. sacchari (44%) from sugarcane bagasse. The largest populations of T. vulgaris and T. thalpophilus were found in paddy straw, followed by T. sacchari, S. viridis and F. rectivirgula in sugar-cane bagasse. The widespread occurrence of these clinically important thermophilic actinomycetes suggests that exposure of humans and animals to them may be frequent in north-western India. Studies are required to determine the prevalence of extrinsic allergic alveolitis (hypersensitivity pneumonitis) caused by thermophilic actinomycetes in the local population.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1572-9699
    Keywords: precipitating antibodies to thermophilic actinomycetes ; Faenia rectivirgula ; Saccharomonospora viridis ; dairy herd workers ; Ouchterlony's double diffusion test ; counterimmunoelectrophoresis ; enzyme-linked immunosorbent assay
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The study was prompted by the lack of information on the role of thermophilic actinomycetes in hypersensitivity pneumonitis in India. It reports the occurrence of precipitating antibodies against clinically important thermophilic actinomycetes in the sera of a population sample of dairy herd workers, Nangali, Delhi. Of 112 workers investigated, 28 (25%) showed precipitins againstFaenia rectivirgula, 4 (3.2%) againstSaccharomonospora viridis, 2 againstThermoactinomyces thalpophilus and one each againstT. vulgaris andT. sacchari. The results of enzyme-linked immunosorbent assay (ELISA) indicated that IgG antibody activity againstF. rectivirgula was significantly higher in the symptomatic group than in the asymptomatic group (p〈0.05) of workers and the controls (p〈0.01). Significant difference inF. rectivirgula IgG activity was also obtained between the precipitin-positive symptomatic group and the precipitin-positive asymptomatic group (p〈 0.05). In strong contrast, the IgG antibody activity againstT. thalpophilus was found to be uniformly low. A limited aeromicrobiological sampling of the dairy farm revealedS. viridis (55.8%) to be the commonest species followed byT. vulgaris (19.2%),T. thalpophilus (18.5%),F. rectivirgula (5%) andT. sacchari (15%). On the basis of suggestive clinical and laboratory findings, farmer's lung disease was suspected in four dairy herd workers. A comprehensive clinical evaluation including pulmonary function studies on the dairy herd workers and their long-term follow-up is indicated to determine the extent of respiratory morbidity caused byF. rectivirgula, S. viridis, T. thalpophilus, T. sacchari andT. vulgaris in India.
    Type of Medium: Electronic Resource
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