Publication Date:
1991-11-25
Description:
The complementary DNA encoding a 585-amino acid parathyroid hormone-parathyroid hormone-related peptide (PTH-PTHrP) receptor with seven potential membrane-spanning domains was cloned by COS-7 expression using an opossum kidney cell complementary DNA (cDNA) library. The expressed receptor binds PTH and PTHrP with equal affinity, and both ligands equivalently stimulate adenylate cyclase. Striking homology with the calcitonin receptor and lack of homology with other G protein-linked receptors indicate that receptors for these calcium-regulating hormones are related and represent a new family.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Juppner, H -- Abou-Samra, A B -- Freeman, M -- Kong, X F -- Schipani, E -- Richards, J -- Kolakowski, L F Jr -- Hock, J -- Potts, J T Jr -- Kronenberg, H M -- DK 11794/DK/NIDDK NIH HHS/ -- New York, N.Y. -- Science. 1991 Nov 15;254(5034):1024-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Endocrine Unit, Massachusetts General Hospital, Boston 02114.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1658941" target="_blank"〉PubMed〈/a〉
Keywords:
Amino Acid Sequence
;
Animals
;
Membrane Glycoproteins/chemistry/genetics/metabolism
;
Molecular Sequence Data
;
Opossums
;
Parathyroid Hormone/metabolism
;
Parathyroid Hormone-Related Protein
;
Proteins/metabolism
;
Receptors, Cell Surface/chemistry/*genetics/metabolism
;
Receptors, Parathyroid Hormone
;
Sequence Alignment
;
Solubility
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
Permalink