Publication Date:
1979-10-19
Description:
The I region of the major histocompatibility complex contains immune response genes that display considerable polymorphism; that is, there are many alleles at each locus. These genes regulate the immune response to antigen by mediating intercellular communication among lymphoreticular cells. An analysis of the primary structure of the products of two subregions of (I-A, I-E/C) was undertaken in order to understand the genetic organization of the region, the evolution of the genes and, eventually, their function.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Uhr, J W -- Capra, J D -- Vitetta, E S -- Cook, R G -- New York, N.Y. -- Science. 1979 Oct 19;206(4416):292-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/113876" target="_blank"〉PubMed〈/a〉
Keywords:
Alleles
;
Amino Acid Sequence
;
Antigens, Surface/analysis/*genetics
;
*Cell Communication
;
*Genes, MHC Class II
;
*Immunity, Cellular
;
Lymphocytes/immunology
;
Macromolecular Substances
;
Macrophages/immunology
;
Molecular Weight
;
Polymorphism, Genetic
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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