Publication Date:
1991-08-09
Description:
Previous studies suggested that one or more genes on chromosome 5q21 are responsible for the inheritance of familial adenomatous polyposis (FAP) and Gardner's syndrome (GS), and contribute to tumor development in patients with noninherited forms of colorectal cancer. Two genes on 5q21 that are tightly linked to FAP (MCC and APC) were found to be somatically altered in tumors from sporadic colorectal cancer patients. One of the genes (APC) was also found to be altered by point mutation in the germ line of FAP and GS patients. These data suggest that more than one gene on chromosome 5q21 may contribute to colorectal neoplasia, and that mutations of the APC gene can cause both FAP and GS. The identification of these genes should aid in understanding the pathogenesis of colorectal neoplasia and in the diagnosis and counseling of patients with inherited predispositions to colorectal cancer.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nishisho, I -- Nakamura, Y -- Miyoshi, Y -- Miki, Y -- Ando, H -- Horii, A -- Koyama, K -- Utsunomiya, J -- Baba, S -- Hedge, P -- CA06973/CA/NCI NIH HHS/ -- CA35494/CA/NCI NIH HHS/ -- CA44688/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1991 Aug 9;253(5020):665-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biochemistry, Cancer Institute, Tokyo, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1651563" target="_blank"〉PubMed〈/a〉
Keywords:
Adenomatous Polyposis Coli/*genetics
;
Amino Acid Sequence
;
Base Sequence
;
Chromosome Mapping
;
*Chromosomes, Human, Pair 5
;
Codon/genetics
;
Colonic Neoplasms/*genetics
;
DNA, Neoplasm/genetics/isolation & purification
;
Genetic Linkage
;
Genetic Variation
;
Humans
;
Molecular Sequence Data
;
*Mutation
;
Oligonucleotide Probes
;
Polymerase Chain Reaction/methods
;
Rectal Neoplasms/*genetics
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
Permalink
