ISSN:
1573-8221
Schlagwort(e):
Alzheimer disease
;
neurotransplantation
;
immunocytochemistry
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Biologie
,
Medizin
Notizen:
Abstract Basal forebrain regions were transplanted from mouse embryos with chromosome 16 trisomy into the lateral brain ventricle of healthy adult mice. After 1–12 months, the grafts contained immunoreactive choline- and GABAergic neurons and astroglial cells. Quantitative analysis revealed no neurodegenerative changes in these grafts compared to diploid ones. Pronounced infiltration with T and B cells and activation of micro- and astroglia were found in the grafts with chromosome 16 trisomy and in control specimen.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/BF02433424
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