ISSN:
1572-8927
Keywords:
Alpha-cyclodextrin
;
thermodynamics
;
inclusion complexes
;
aliphatic amines
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract Complexation between α-cyclodextrin (α-CD) and aliphatic amines in water and DMF solvents was studied by calorimetry. Amines form complexes with α-CD in both solvents but the nature of the complexes is quite different. In DMF the amines donate a hydrogen from the amine N−H group to the cyclodextrin forming a normal hydrogen bonded complex. In DMF solutions with large amine concentrations, complexes other than 1∶1 are observed. In contrast, in aqueous environment the amines form inclusion complexes in which the amine alkyl group penetrates the α-CD cavity and is stabilized by van der Waals interactions. The equilibrium constants for the complexes formed in water solvent increase with increasing alkyl chain length due to an entropy effect.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00973782
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