Publication Date:
1997-12-31
Description:
Tiam1 encodes an exchange factor for the Rho-like guanosine triphosphatase Rac. Both Tiam1 and activated RacV12 promote invasiveness of T lymphoma cells. In epithelial Madin-Darby canine kidney (MDCK) cells, Tiam1 localized to adherens junctions. Ectopic expression of Tiam1 or RacV12 inhibited hepatocyte growth factor-induced scattering by increasing E-cadherin-mediated cell-cell adhesion accompanied by actin polymerization at cell-cell contacts. In Ras-transformed MDCK cells, expression of Tiam1 or RacV12 restored E-cadherin-mediated adhesion, resulting in phenotypic reversion and loss of invasiveness. These data suggest an invasion-suppressor role for Tiam1 and Rac in epithelial cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hordijk, P L -- ten Klooster, J P -- van der Kammen, R A -- Michiels, F -- Oomen, L C -- Collard, J G -- New York, N.Y. -- Science. 1997 Nov 21;278(5342):1464-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Cell Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, Netherlands.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9367959" target="_blank"〉PubMed〈/a〉
Keywords:
Actins/metabolism
;
Animals
;
Cadherins/metabolism
;
*Cell Adhesion
;
Cell Line
;
Cell Line, Transformed
;
Cell Movement
;
Cell Transformation, Neoplastic
;
Cytoplasm/metabolism
;
Epithelial Cells/*cytology/metabolism
;
GTP-Binding Proteins/*metabolism
;
Hepatocyte Growth Factor/pharmacology
;
Intercellular Junctions/*metabolism
;
*Neoplasm Invasiveness
;
Phenotype
;
Proteins/genetics/*metabolism
;
Signal Transduction
;
rac GTP-Binding Proteins
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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