ISSN:
1420-9071
Keywords:
Adenine arabinoside 5-monophosphate
;
drug targeting
;
hepatitis B
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Summary In plasma of mice injected with adenine-9-β-D-arabinofuranoside monophosphate (ara-AMP) coupled to human lactosaminated serum albumin (L-HSA) some of the ara-AMP molecules are enzymatically released, whereas others remain linked to L-HSA. Evidence has been obtained that ara-AMP is not deaminated when it is conjugated to L-HSA, in contrast to the free drug which is rapidly metabolized to its hypoxanthine derivative.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01952078
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